Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies

Interleukin 6 plays a key role in mediating inflammatory reactions in autoimmune diseases and cancer, where it is also involved in metastasis and tissue invasion. Neutralizing antibodies against IL-6 and its receptor have been approved for therapeutic intervention or are in advanced stages of clinic...

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Detalles Bibliográficos
Autores principales: Blanchetot, Christophe, De Jonge, Natalie, Desmyter, Aline, Ongenae, Nico, Hofman, Erik, Klarenbeek, Alex, Sadi, Ava, Hultberg, Anna, Kretz-Rommel, Anke, Spinelli, Silvia, Loris, Remy, Cambillau, Christian, de Haard, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919466/
https://www.ncbi.nlm.nih.gov/pubmed/27129274
http://dx.doi.org/10.1074/jbc.M115.695528

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