Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

Fanconi Anemia (FA) is a genetic disorder characterized by elevated cancer susceptibility and pro-inflammatory cytokine production. Using SLX4(FANCP) deficiency as a working model, we questioned the trigger for chronic inflammation in FA. We found that absence of SLX4 caused cytoplasmic DNA accumula...

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Detalles Bibliográficos
Autores principales: Brégnard, Christelle, Guerra, Jessica, Déjardin, Stéphanie, Passalacqua, Frank, Benkirane, Monsef, Laguette, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919473/
https://www.ncbi.nlm.nih.gov/pubmed/27428429
http://dx.doi.org/10.1016/j.ebiom.2016.05.005

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