A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics

Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications is of great interest. Here we screened > 320.000 compounds for their ability to prevent a cellular lipid accumulation phe...

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Detalles Bibliográficos
Autores principales: Tschapalda, Kirsten, Zhang, Ya-Qin, Liu, Li, Golovnina, Kseniya, Schlemper, Thomas, Eichmann, Thomas O., Lal-Nag, Madhu, Sreenivasan, Urmila, McLenithan, John, Ziegler, Slava, Sztalryd, Carole, Lass, Achim, Auld, Douglas, Oliver, Brian, Waldmann, Herbert, Li, Zhuyin, Shen, Min, Boxer, Matthew B., Beller, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919474/
https://www.ncbi.nlm.nih.gov/pubmed/27428418
http://dx.doi.org/10.1016/j.ebiom.2016.04.014

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