Cargando…

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus

BACKGROUND AND PURPOSE: Previous findings suggest that the growth and differentiation factor midkine (Mdk) is a negative regulator of osteoblast activity and bone formation, thereby raising the possibility that a specific Mdk antagonist might improve bone formation during fracture healing. EXPERIMEN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haffner‐Luntzer, Melanie, Heilmann, Aline, Rapp, Anna Elise, Roessler, Robin, Schinke, Thorsten, Amling, Michael, Ignatius, Anita, Liedert, Astrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919577/ https://www.ncbi.nlm.nih.gov/pubmed/27111560 http://dx.doi.org/10.1111/bph.13503

Ejemplares similares

Midkine-Deficiency Delays Chondrogenesis during the Early Phase of Fracture Healing in Mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2014)

Inhibition of Midkine Augments Osteoporotic Fracture Healing
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2016)

The Wnt Serpentine Receptor Frizzled-9 Regulates New Bone Formation in Fracture Healing
por: Heilmann, Aline, et al.
Publicado: (2013)

Hypochlorhydria‐induced calcium malabsorption does not affect fracture healing but increases post‐traumatic bone loss in the intact skeleton
por: Haffner‐Luntzer, Melanie, et al.
Publicado: (2016)

The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice
por: Wehrle, Esther, et al.
Publicado: (2015)

Mechanobiology of bone remodeling and fracture healing in the aged organism
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2016)

The inflammatory phase of fracture healing is influenced by oestrogen status in mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2017)

Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice
por: Fischer, Verena, et al.
Publicado: (2017)

Influence of Menopause on Inflammatory Cytokines during Murine and Human Bone Fracture Healing
por: Fischer, Verena, et al.
Publicado: (2018)

Publisher Correction: Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice
por: Fischer, Verena, et al.
Publicado: (2018)

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing
por: Bergdolt, Stephanie, et al.
Publicado: (2017)

Osteoblast-Specific Krm2 Overexpression and Lrp5 Deficiency Have Different Effects on Fracture Healing in Mice
por: Liedert, Astrid, et al.
Publicado: (2014)

Differences in Fracture Healing Between Female and Male C57BL/6J Mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2021)

Influence of Low-Magnitude High-Frequency Vibration on Bone Cells and Bone Regeneration
por: Steppe, Lena, et al.
Publicado: (2020)

Numerical Simulation of Callus Healing for Optimization of Fracture Fixation Stiffness
por: Steiner, Malte, et al.
Publicado: (2014)

Effects of Estrogen Receptor and Wnt Signaling Activation on Mechanically Induced Bone Formation in a Mouse Model of Postmenopausal Bone Loss
por: Liedert, Astrid, et al.
Publicado: (2020)

Estrogen Receptor α Signaling in Osteoblasts is Required for Mechanotransduction in Bone Fracture Healing
por: Steppe, Lena, et al.
Publicado: (2021)

Evaluation of high-resolution In Vivo MRI for longitudinal analysis of endochondral fracture healing in mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2017)

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma
por: Kaiser, Kathrin, et al.
Publicado: (2018)

CXCR4 Antagonism to Treat Delayed Fracture Healing
por: Meeson, Richard, et al.
Publicado: (2019)

Complement C3 and C5 Deficiency Affects Fracture Healing
por: Ehrnthaller, Christian, et al.
Publicado: (2013)

Prediction of the Time Course of Callus Stiffness as a Function of Mechanical Parameters in Experimental Rat Fracture Healing Studies - A Numerical Study
por: Wehner, Tim, et al.
Publicado: (2014)

Altered early immune response after fracture and traumatic brain injury
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2023)

Comparison between Different Methods for Biomechanical Assessment of Ex Vivo Fracture Callus Stiffness in Small Animal Bone Healing Studies
por: Steiner, Malte, et al.
Publicado: (2015)

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
por: Riegger, Jana, et al.
Publicado: (2023)

Induced global deletion of glucocorticoid receptor impairs fracture healing
por: Rapp, Anna E., et al.
Publicado: (2018)

On Provisional Callus in Fractured Bones
por: Hamilton, Frank H.
Publicado: (1853)

Systemic and Cardiac Alterations After Long Bone Fracture
por: Weber, Birte, et al.
Publicado: (2020)

C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing
por: Ehrnthaller, Christian, et al.
Publicado: (2016)

C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast‐inducing chemokine CXCL10
por: Mödinger, Yvonne, et al.
Publicado: (2018)

Efficacy and Safety of Teriparatide in Improving Fracture Healing and Callus Formation: A Systematic Review
por: Puvvada, Chaitanya S, et al.
Publicado: (2023)

Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells
por: Steppe, Lena, et al.
Publicado: (2022)

Correction: Steppe et al. Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells. Int. J. Mol. Sci. 2022, 23, 2902
por: Steppe, Lena, et al.
Publicado: (2022)

Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing
por: Hachemi, Yasmine, et al.
Publicado: (2021)

Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism
por: Lackner, Ina, et al.
Publicado: (2019)

Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process
por: Wang, Lei, et al.
Publicado: (2017)

Odanacatib increases mineralized callus during fracture healing in a rabbit ulnar osteotomy model
por: Pennypacker, Brenda L., et al.
Publicado: (2015)

Bone morphogenetic protein 9 stimulates callus formation in osteoporotic rats during fracture healing
por: Wang, Xing, et al.
Publicado: (2017)

Three-Dimensional Computational Model Simulating the Initial Callus Growth during Fracture Healing in Long Bones: Application to Different Fracture Types
por: Naveiro, José M., et al.
Publicado: (2023)

Short-wave enhances mesenchymal stem cell recruitment in fracture healing by increasing HIF-1 in callus
por: Ye, Dongmei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kjta3pco1bes0ec98htbcghv9d