Cargando…

GPCRdb: the G protein‐coupled receptor database – an introduction

GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Munk, C, Isberg, V, Mordalski, S, Harpsøe, K, Rataj, K, Hauser, A S, Kolb, P, Bojarski, A J, Vriend, G, Gloriam, D E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919580/ https://www.ncbi.nlm.nih.gov/pubmed/27155948 http://dx.doi.org/10.1111/bph.13509

Ejemplares similares

GPCRdb: an information system for G protein-coupled receptors
por: Isberg, Vignir, et al.
Publicado: (2016)

GPCRdb: an information system for G protein-coupled receptors
por: Isberg, Vignir, et al.
Publicado: (2017)

GPCRDB: an information system for G protein-coupled receptors
por: Isberg, Vignir, et al.
Publicado: (2014)

GPCRdb in 2018: adding GPCR structure models and ligands
por: Pándy-Szekeres, Gáspár, et al.
Publicado: (2018)

GPCRDB: information system for G protein-coupled receptors
por: Vroling, Bas, et al.
Publicado: (2011)

GPCRdb in 2021: integrating GPCR sequence, structure and function
por: Kooistra, Albert J, et al.
Publicado: (2020)

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
por: Shehata, Mohamed A., et al.
Publicado: (2016)

GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources
por: Pándy-Szekeres, Gáspár, et al.
Publicado: (2022)

Multiple conformational states in retrospective virtual screening – homology models vs. crystal structures: beta-2 adrenergic receptor case study
por: Mordalski, Stefan, et al.
Publicado: (2015)

The G protein database, GproteinDb
por: Pándy-Szekeres, Gáspár, et al.
Publicado: (2021)

The importance of template choice in homology modeling. A 5-HT(6)R case study
por: Rataj, Krzysztof, et al.
Publicado: (2013)

The G protein-coupled receptor subset of the rat genome
por: Gloriam, David E, et al.
Publicado: (2007)

Application of Structural Interaction Fingerpints (SIFts) into post-docking analysis - insight into activity and selectivity
por: Witek, Jagna, et al.
Publicado: (2013)

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants
por: Harpsøe, Kasper, et al.
Publicado: (2015)

Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139
por: Zhou, Yali, et al.
Publicado: (2021)

Alpha-Bulges in G Protein-Coupled Receptors
por: van der Kant, Rob, et al.
Publicado: (2014)

Homology modelling of metabotropic glutamate receptor 2
por: Mordalski, S, et al.
Publicado: (2011)

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs
por: Harpsøe, Kasper, et al.
Publicado: (2017)

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
por: Nøhr, Anne Cathrine, et al.
Publicado: (2017)

Pharmacology and function of the orphan GPR139 G protein‐coupled receptor
por: Vedel, Line, et al.
Publicado: (2019)

The G Protein–Coupled Receptor Subset of the Chicken Genome
por: Lagerström, Malin C, et al.
Publicado: (2006)

Gα(i)-derived peptide binds the µ-opioid receptor
por: Kossoń, Piotr, et al.
Publicado: (2023)

Bioisosteric Matrices for Ligands of Serotonin Receptors
por: Warszycki, Dawid, et al.
Publicado: (2015)

Common coupling map advances GPCR-G protein selectivity
por: Hauser, Alexander S, et al.
Publicado: (2022)

Rapid binding site analysis by means of structural interaction fingerprint patterns – an implication to GPCR-targeted CADD
por: Kosciolek, T, et al.
Publicado: (2011)

2D SIFt: a matrix of ligand-receptor interactions
por: Mordalski, Stefan, et al.
Publicado: (2021)

The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents
por: Haitina, Tatjana, et al.
Publicado: (2009)

Data-Driven Analysis of Fluorination of Ligands of Aminergic G Protein Coupled Receptors
por: Pietruś, Wojciech, et al.
Publicado: (2021)

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
por: Foster, Simon R., et al.
Publicado: (2019)

Ligand-guided homology modelling of the GABA(B2) subunit of the GABA(B) receptor
por: Freyd, Thibaud, et al.
Publicado: (2017)

RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling
por: Fang, Yu-Ching, et al.
Publicado: (2006)

Systematic generation of in vivo G protein-coupled receptor mutants in the rat
por: van Boxtel, R, et al.
Publicado: (2011)

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
por: Harmar, Anthony J., et al.
Publicado: (2009)

Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands
por: Pietruś, Wojciech, et al.
Publicado: (2023)

Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin 5-HT(2) Receptors
por: Isberg, Vignir, et al.
Publicado: (2013)

Identification of Histamine H(3) Receptor Ligands Using a New Crystal Structure Fragment-based Method
por: Frandsen, Ida Osborn, et al.
Publicado: (2017)

Correction: Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin 5-HT(2) Receptors
por: Isberg, Vignir, et al.
Publicado: (2014)

Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa
por: Li, Shizhong, et al.
Publicado: (2016)

Using random forests for assistance in the curation of G-protein coupled receptor databases
por: Shkurin, Aleksei, et al.
Publicado: (2017)

A Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New Active Compounds – An Application for 5-HT(1A) Receptor Ligands
por: Warszycki, Dawid, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_p2ni7nh280f1v314outd9lktrc