Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations

Recent studies have identified human myxovirus resistance protein 2 (MxB or Mx2) as an interferon induced inhibitor of HIV-1 replication. However, whether HIV-1 can overcome MxB restriction without compromise of viral fitness has been undefined. Here, we have discovered that naturally occurring caps...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Guo, Haoran, Ma, Min, Markham, Richard, Yu, Xiao-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919602/
https://www.ncbi.nlm.nih.gov/pubmed/27428433
http://dx.doi.org/10.1016/j.ebiom.2016.04.020

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