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Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure o...
Autores principales: | Illendula, Anuradha, Gilmour, Jane, Grembecka, Jolanta, Tirumala, Venkata Sesha Srimath, Boulton, Adam, Kuntimaddi, Aravinda, Schmidt, Charles, Wang, Lixin, Pulikkan, John A., Zong, Hongliang, Parlak, Mahmut, Kuscu, Cem, Pickin, Anna, Zhou, Yunpeng, Gao, Yan, Mishra, Lauren, Adli, Mazhar, Castilla, Lucio H., Rajewski, Roger A., Janes, Kevin A., Guzman, Monica L., Bonifer, Constanze, Bushweller, John H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919611/ https://www.ncbi.nlm.nih.gov/pubmed/27428424 http://dx.doi.org/10.1016/j.ebiom.2016.04.032 |
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