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A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics

It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence...

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Autores principales: Chaillon, Antoine, Hoenigl, Martin, Mehta, Sanjay R., Weibel, Nadir, Little, Susan J., Smith, Davey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919622/
https://www.ncbi.nlm.nih.gov/pubmed/27337983
http://dx.doi.org/10.1038/srep28707
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author Chaillon, Antoine
Hoenigl, Martin
Mehta, Sanjay R.
Weibel, Nadir
Little, Susan J.
Smith, Davey M.
author_facet Chaillon, Antoine
Hoenigl, Martin
Mehta, Sanjay R.
Weibel, Nadir
Little, Susan J.
Smith, Davey M.
author_sort Chaillon, Antoine
collection PubMed
description It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are needed to substantially reduce the HIV epidemic in San Diego, which is predominately comprised of men who have sex with men. By increasing the proportion of HIV-infected individuals on ART from 30% to 50%, 686 new infections would be prevented over five years in San Diego. By providing PrEP to 30% of MSM to the age group that account for 90% of local HIV incident cases (21–52 years), we could prevent 433 infections over five years. When combining these initiatives, a PrEP coverage rate of 40% and TasP coverage rate of 34% would be expected to decrease the number of new infections by over half in one year. This online tool is designed to help local public health planners and policy makers to estimate program outcomes and costs that may lead to better control of their local HIV epidemics.
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spelling pubmed-49196222016-06-28 A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics Chaillon, Antoine Hoenigl, Martin Mehta, Sanjay R. Weibel, Nadir Little, Susan J. Smith, Davey M. Sci Rep Article It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are needed to substantially reduce the HIV epidemic in San Diego, which is predominately comprised of men who have sex with men. By increasing the proportion of HIV-infected individuals on ART from 30% to 50%, 686 new infections would be prevented over five years in San Diego. By providing PrEP to 30% of MSM to the age group that account for 90% of local HIV incident cases (21–52 years), we could prevent 433 infections over five years. When combining these initiatives, a PrEP coverage rate of 40% and TasP coverage rate of 34% would be expected to decrease the number of new infections by over half in one year. This online tool is designed to help local public health planners and policy makers to estimate program outcomes and costs that may lead to better control of their local HIV epidemics. Nature Publishing Group 2016-06-24 /pmc/articles/PMC4919622/ /pubmed/27337983 http://dx.doi.org/10.1038/srep28707 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chaillon, Antoine
Hoenigl, Martin
Mehta, Sanjay R.
Weibel, Nadir
Little, Susan J.
Smith, Davey M.
A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics
title A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics
title_full A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics
title_fullStr A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics
title_full_unstemmed A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics
title_short A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics
title_sort practical online tool to estimate antiretroviral coverage for hiv infected and susceptible populations needed to reduce local hiv epidemics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919622/
https://www.ncbi.nlm.nih.gov/pubmed/27337983
http://dx.doi.org/10.1038/srep28707
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