Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect

TGR5 activation of enteroendocrine cells increases glucagon-like peptide 1 (GLP-1) release, which maintains glycemic homeostasis. However, TGR5 activation in the gallbladder and heart is associated with severe side effects. Therefore, intestinally-targeted TGR5 agonists were suggested as potential h...

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Detalles Bibliográficos
Autores principales: Cao, Hua, Chen, Zhi-Xiang, Wang, Kai, Ning, Meng-Meng, Zou, Qing-An, Feng, Ying, Ye, Yang-Liang, Leng, Ying, Shen, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919643/
https://www.ncbi.nlm.nih.gov/pubmed/27339735
http://dx.doi.org/10.1038/srep28676

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