Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore

[Image: see text] We describe a general method to synthesize the iminium tetrahydrothiophene embedded in the dimeric Nuphar alkaloids. In contrast to prior studies, the sulfur atom of the thiaspirane pharmacophore is shown to be electrophilic. This α-thioether reacts with thiophenol or glutathione a...

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Detalles Bibliográficos
Autores principales: Tada, Norihiro, Jansen, Daniel J., Mower, Matthew P., Blewett, Megan M., Umotoy, Jeffrey C., Cravatt, Benjamin F., Wolan, Dennis W., Shenvi, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919772/
https://www.ncbi.nlm.nih.gov/pubmed/27413784
http://dx.doi.org/10.1021/acscentsci.6b00113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919772/
https://www.ncbi.nlm.nih.gov/pubmed/27413784
http://dx.doi.org/10.1021/acscentsci.6b00113

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