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Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore
[Image: see text] We describe a general method to synthesize the iminium tetrahydrothiophene embedded in the dimeric Nuphar alkaloids. In contrast to prior studies, the sulfur atom of the thiaspirane pharmacophore is shown to be electrophilic. This α-thioether reacts with thiophenol or glutathione a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919772/ https://www.ncbi.nlm.nih.gov/pubmed/27413784 http://dx.doi.org/10.1021/acscentsci.6b00113 |