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Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

BACKGROUND: Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (GRN) are a common cause of frontotemporal lobar degeneration (FTLD) and lead to disease through PGRN haploinsufficiency....

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Detalles Bibliográficos
Autores principales:	Holler, Christopher J., Taylor, Georgia, McEachin, Zachary T., Deng, Qiudong, Watkins, William J., Hudson, Kathryn, Easley, Charles A., Hu, William T., Hales, Chadwick M., Rossoll, Wilfried, Bassell, Gary J., Kukar, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919863/ https://www.ncbi.nlm.nih.gov/pubmed/27341800 http://dx.doi.org/10.1186/s13024-016-0114-3

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