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Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales

BACKGROUND: Listeriosis is an opportunistic bacterial infection caused by Listeria monocytogenes and predominantly affects people who are immunocompromised. Due to its severity and the population at risk, prompt clinical diagnosis and treatment of listeriosis is essential. A major step to making a c...

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Autores principales: Awofisayo-Okuyelu, Adedoyin, Verlander, Neville Q., Amar, Corinne, Elson, Richard, Grant, Kathie, Harris, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919868/
https://www.ncbi.nlm.nih.gov/pubmed/27341796
http://dx.doi.org/10.1186/s12879-016-1638-4
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author Awofisayo-Okuyelu, Adedoyin
Verlander, Neville Q.
Amar, Corinne
Elson, Richard
Grant, Kathie
Harris, John
author_facet Awofisayo-Okuyelu, Adedoyin
Verlander, Neville Q.
Amar, Corinne
Elson, Richard
Grant, Kathie
Harris, John
author_sort Awofisayo-Okuyelu, Adedoyin
collection PubMed
description BACKGROUND: Listeriosis is an opportunistic bacterial infection caused by Listeria monocytogenes and predominantly affects people who are immunocompromised. Due to its severity and the population at risk, prompt clinical diagnosis and treatment of listeriosis is essential. A major step to making a clinical diagnosis is the collection of the appropriate specimen(s) for testing. This study explores factors that may influence the time between onset of illness and collection of specimen in order to inform clinical policy and develop necessary interventions. METHODS: Enhanced surveillance data on non-pregnancy associated listeriosis in England and Wales between 2004 and 2013 were collected and analysed. The difference in days between onset of symptoms and collection of specimen was calculated and factors influencing the time difference were identified using a gamma regression model. RESULTS: The median number of days between onset of symptoms and collection of specimen was two days with 27.1 % of cases reporting one day between onset of symptoms and collection of specimen and 18.8 % of cases reporting more than seven days before collection of specimen. The median number of days between onset of symptoms and collection of specimen was shorter for cases infected with Listeria monocytogenes serogroup 1/2b (one day) and cases with an underlying condition (one day) compared with cases infected with serotype 4 (two days) and cases without underlying conditions (two days). CONCLUSIONS: Our study has shown that Listeria monocytogenes serotype and the presence of an underlying condition may influence the time between onset of symptoms and collection of specimen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-1638-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-49198682016-06-28 Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales Awofisayo-Okuyelu, Adedoyin Verlander, Neville Q. Amar, Corinne Elson, Richard Grant, Kathie Harris, John BMC Infect Dis Research Article BACKGROUND: Listeriosis is an opportunistic bacterial infection caused by Listeria monocytogenes and predominantly affects people who are immunocompromised. Due to its severity and the population at risk, prompt clinical diagnosis and treatment of listeriosis is essential. A major step to making a clinical diagnosis is the collection of the appropriate specimen(s) for testing. This study explores factors that may influence the time between onset of illness and collection of specimen in order to inform clinical policy and develop necessary interventions. METHODS: Enhanced surveillance data on non-pregnancy associated listeriosis in England and Wales between 2004 and 2013 were collected and analysed. The difference in days between onset of symptoms and collection of specimen was calculated and factors influencing the time difference were identified using a gamma regression model. RESULTS: The median number of days between onset of symptoms and collection of specimen was two days with 27.1 % of cases reporting one day between onset of symptoms and collection of specimen and 18.8 % of cases reporting more than seven days before collection of specimen. The median number of days between onset of symptoms and collection of specimen was shorter for cases infected with Listeria monocytogenes serogroup 1/2b (one day) and cases with an underlying condition (one day) compared with cases infected with serotype 4 (two days) and cases without underlying conditions (two days). CONCLUSIONS: Our study has shown that Listeria monocytogenes serotype and the presence of an underlying condition may influence the time between onset of symptoms and collection of specimen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-1638-4) contains supplementary material, which is available to authorized users. BioMed Central 2016-06-24 /pmc/articles/PMC4919868/ /pubmed/27341796 http://dx.doi.org/10.1186/s12879-016-1638-4 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Awofisayo-Okuyelu, Adedoyin
Verlander, Neville Q.
Amar, Corinne
Elson, Richard
Grant, Kathie
Harris, John
Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales
title Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales
title_full Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales
title_fullStr Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales
title_full_unstemmed Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales
title_short Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales
title_sort factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in england and wales
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919868/
https://www.ncbi.nlm.nih.gov/pubmed/27341796
http://dx.doi.org/10.1186/s12879-016-1638-4
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