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Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment

BACKGROUND: Aberrant patterns of DNA methylation are abundant in cancer, and epigenetic pathways are increasingly being targeted in cancer drug treatment. Genetic components of the folate-mediated one-carbon metabolism pathway can affect DNA methylation and other vital cell functions, including DNA...

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Detalles Bibliográficos
Autores principales:	Krushkal, Julia, Zhao, Yingdong, Hose, Curtis, Monks, Anne, Doroshow, James H., Simon, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919895/ https://www.ncbi.nlm.nih.gov/pubmed/27347216 http://dx.doi.org/10.1186/s13148-016-0240-3

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