Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome

Lactobacillus plantarum WCFS1 is one of the best studied Lactobacilli, notably as its genome was unravelled over 12 years ago. L. plantarum WCFS1 can be grown to high densities, is amenable to genetic transformation and highly robust with a relatively high survival rate during the gastrointestinal p...

Descripción completa

Detalles Bibliográficos
Autores principales: van den Nieuwboer, Maurits, van Hemert, Saskia, Claassen, Eric, de Vos, Willem M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919987/
https://www.ncbi.nlm.nih.gov/pubmed/27231133
http://dx.doi.org/10.1111/1751-7915.12368
_version_ 1782439337100574720
author van den Nieuwboer, Maurits
van Hemert, Saskia
Claassen, Eric
de Vos, Willem M.
author_facet van den Nieuwboer, Maurits
van Hemert, Saskia
Claassen, Eric
de Vos, Willem M.
author_sort van den Nieuwboer, Maurits
collection PubMed
description Lactobacillus plantarum WCFS1 is one of the best studied Lactobacilli, notably as its genome was unravelled over 12 years ago. L. plantarum WCFS1 can be grown to high densities, is amenable to genetic transformation and highly robust with a relatively high survival rate during the gastrointestinal passage. In this review, we present and discuss the main insights provided by the functional genomics research on L. plantarum WCFS1 with specific attention for the molecular mechanisms related to its interaction with the human host and its potential to modify the immune system, and induce other health‐related benefits. Whereas most insight has been gained in mouse and other model studies, only five human studies have been reported with L. plantarum WCFS1. Hence NCIMB 8826 (the parental strain of L. plantarum WCFS1) in human trials as to capitalize on the wealth of knowledge that is summarized here.
format Online
Article
Text
id pubmed-4919987
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-49199872016-06-28 Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome van den Nieuwboer, Maurits van Hemert, Saskia Claassen, Eric de Vos, Willem M. Microb Biotechnol Minireviews Lactobacillus plantarum WCFS1 is one of the best studied Lactobacilli, notably as its genome was unravelled over 12 years ago. L. plantarum WCFS1 can be grown to high densities, is amenable to genetic transformation and highly robust with a relatively high survival rate during the gastrointestinal passage. In this review, we present and discuss the main insights provided by the functional genomics research on L. plantarum WCFS1 with specific attention for the molecular mechanisms related to its interaction with the human host and its potential to modify the immune system, and induce other health‐related benefits. Whereas most insight has been gained in mouse and other model studies, only five human studies have been reported with L. plantarum WCFS1. Hence NCIMB 8826 (the parental strain of L. plantarum WCFS1) in human trials as to capitalize on the wealth of knowledge that is summarized here. John Wiley and Sons Inc. 2016-05-27 /pmc/articles/PMC4919987/ /pubmed/27231133 http://dx.doi.org/10.1111/1751-7915.12368 Text en © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireviews
van den Nieuwboer, Maurits
van Hemert, Saskia
Claassen, Eric
de Vos, Willem M.
Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
title Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
title_full Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
title_fullStr Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
title_full_unstemmed Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
title_short Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
title_sort lactobacillus plantarum wcfs1 and its host interaction: a dozen years after the genome
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919987/
https://www.ncbi.nlm.nih.gov/pubmed/27231133
http://dx.doi.org/10.1111/1751-7915.12368
work_keys_str_mv AT vandennieuwboermaurits lactobacillusplantarumwcfs1anditshostinteractionadozenyearsafterthegenome
AT vanhemertsaskia lactobacillusplantarumwcfs1anditshostinteractionadozenyearsafterthegenome
AT claasseneric lactobacillusplantarumwcfs1anditshostinteractionadozenyearsafterthegenome
AT devoswillemm lactobacillusplantarumwcfs1anditshostinteractionadozenyearsafterthegenome

Ejemplares similares