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Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings

Conducting clinical trials to prevent and treat infectious diseases in pregnancy is essential to saving maternal and newborn lives, though it is fraught with challenges. We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a...

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Detalles Bibliográficos
Autores principales: Divala, Titus H., Mungwira, Randy G., Laufer, Miriam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920047/
https://www.ncbi.nlm.nih.gov/pubmed/26319059
http://dx.doi.org/10.1016/j.vaccine.2015.08.042
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author Divala, Titus H.
Mungwira, Randy G.
Laufer, Miriam K.
author_facet Divala, Titus H.
Mungwira, Randy G.
Laufer, Miriam K.
author_sort Divala, Titus H.
collection PubMed
description Conducting clinical trials to prevent and treat infectious diseases in pregnancy is essential to saving maternal and newborn lives, though it is fraught with challenges. We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a decade. Here, we review some of the unique challenges that we have faced in leading research studies that with rigor and integrity and maintaining the highest ethical standard. We conclude with concrete strategies to overcome some of the apparent obstacles that frequently focus on building trust through bidirectional communication with local health workers and communities. We also highlight the key role of local and international investigators to advocate for the health of the communities in which they work.
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spelling pubmed-49200472016-06-24 Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings Divala, Titus H. Mungwira, Randy G. Laufer, Miriam K. Vaccine Article Conducting clinical trials to prevent and treat infectious diseases in pregnancy is essential to saving maternal and newborn lives, though it is fraught with challenges. We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a decade. Here, we review some of the unique challenges that we have faced in leading research studies that with rigor and integrity and maintaining the highest ethical standard. We conclude with concrete strategies to overcome some of the apparent obstacles that frequently focus on building trust through bidirectional communication with local health workers and communities. We also highlight the key role of local and international investigators to advocate for the health of the communities in which they work. 2015-08-25 2015-11-25 /pmc/articles/PMC4920047/ /pubmed/26319059 http://dx.doi.org/10.1016/j.vaccine.2015.08.042 Text en This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Divala, Titus H.
Mungwira, Randy G.
Laufer, Miriam K.
Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings
title Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings
title_full Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings
title_fullStr Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings
title_full_unstemmed Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings
title_short Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings
title_sort moving targets: the challenges of studying infectious diseases among pregnant women in resource limited settings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920047/
https://www.ncbi.nlm.nih.gov/pubmed/26319059
http://dx.doi.org/10.1016/j.vaccine.2015.08.042
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