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Cas-Database: web-based genome-wide guide RNA library design for gene knockout screens using CRISPR-Cas9
Motivation: CRISPR-derived RNA guided endonucleases (RGENs) have been widely used for both gene knockout and knock-in at the level of single or multiple genes. RGENs are now available for forward genetic screens at genome scale, but single guide RNA (sgRNA) selection at this scale is difficult. Resu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920116/ https://www.ncbi.nlm.nih.gov/pubmed/27153724 http://dx.doi.org/10.1093/bioinformatics/btw103 |