High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive heterotopic endochondral ossification leading to...

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Detalles Bibliográficos
Autores principales: Cappato, Serena, Tonachini, Laura, Giacopelli, Francesca, Tirone, Mario, Galietta, Luis J. V., Sormani, Martina, Giovenzana, Anna, Spinelli, Antonello E., Canciani, Barbara, Brunelli, Silvia, Ravazzolo, Roberto, Bocciardi, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920148/
https://www.ncbi.nlm.nih.gov/pubmed/27125279
http://dx.doi.org/10.1242/dmm.023929

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