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Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase–Independent Effects

BACKGROUND—: Plasma triglyceride levels have been implicated in atherosclerosis and coronary heart disease. Apolipoprotein C-III (APOC3) plays a key role in the hydrolysis of triglyceride-rich lipoproteins to remnant particles by lipoprotein lipase (LPL) and their uptake by the liver. A rare variant...

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Detalles Bibliográficos
Autores principales:	Drenos, Fotios, Davey Smith, George, Ala-Korpela, Mika, Kettunen, Johannes, Würtz, Peter, Soininen, Pasi, Kangas, Antti J., Dale, Caroline, Lawlor, Debbie A., Gaunt, Tom R., Casas, Juan-Pablo, Timpson, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920206/ https://www.ncbi.nlm.nih.gov/pubmed/27114411 http://dx.doi.org/10.1161/CIRCGENETICS.115.001302

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