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Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss

BACKGROUND: New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothal...

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Autores principales: Martin, Tristan, Moussay, Sébastien, Bulla, Ingo, Bulla, Jan, Toupet, Michel, Etard, Olivier, Denise, Pierre, Davenne, Damien, Coquerel, Antoine, Quarck, Gaëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920359/
https://www.ncbi.nlm.nih.gov/pubmed/27341473
http://dx.doi.org/10.1371/journal.pone.0155067
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author Martin, Tristan
Moussay, Sébastien
Bulla, Ingo
Bulla, Jan
Toupet, Michel
Etard, Olivier
Denise, Pierre
Davenne, Damien
Coquerel, Antoine
Quarck, Gaëlle
author_facet Martin, Tristan
Moussay, Sébastien
Bulla, Ingo
Bulla, Jan
Toupet, Michel
Etard, Olivier
Denise, Pierre
Davenne, Damien
Coquerel, Antoine
Quarck, Gaëlle
author_sort Martin, Tristan
collection PubMed
description BACKGROUND: New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothalamic regulation of circadian rhythms on Earth, which raises the question of whether daily rhythms might be altered due to vestibular pathology in humans. The aim of this study was to evaluate human circadian rhythmicity in people presenting a total bilateral vestibular loss (BVL) in comparison with control participants. METHODOLOGY AND PRINCIPAL FINDINGS: Nine patients presenting a total idiopathic BVL and 8 healthy participants were compared. Their rest-activity cycle was recorded by actigraphy at home over 2 weeks. The daily rhythm of temperature was continuously recorded using a telemetric device and salivary cortisol was recorded every 3 hours from 6:00AM to 9:00PM over 24 hours. BVL patients displayed a similar rest activity cycle during the day to control participants but had higher nocturnal actigraphy, mainly during weekdays. Sleep efficiency was reduced in patients compared to control participants. Patients had a marked temperature rhythm but with a significant phase advance (73 min) and a higher variability of the acrophase (from 2:24 PM to 9:25 PM) with no correlation to rest-activity cycle, contrary to healthy participants. Salivary cortisol levels were higher in patients compared to healthy people at any time of day. CONCLUSION: We observed a marked circadian rhythmicity of temperature in patients with BVL, probably due to the influence of the light dark cycle. However, the lack of synchronization between the temperature and rest-activity cycle supports the hypothesis that the vestibular inputs are salient input to the circadian clock that enhance the stabilization and precision of both external and internal entrainment.
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spelling pubmed-49203592016-07-18 Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss Martin, Tristan Moussay, Sébastien Bulla, Ingo Bulla, Jan Toupet, Michel Etard, Olivier Denise, Pierre Davenne, Damien Coquerel, Antoine Quarck, Gaëlle PLoS One Research Article BACKGROUND: New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothalamic regulation of circadian rhythms on Earth, which raises the question of whether daily rhythms might be altered due to vestibular pathology in humans. The aim of this study was to evaluate human circadian rhythmicity in people presenting a total bilateral vestibular loss (BVL) in comparison with control participants. METHODOLOGY AND PRINCIPAL FINDINGS: Nine patients presenting a total idiopathic BVL and 8 healthy participants were compared. Their rest-activity cycle was recorded by actigraphy at home over 2 weeks. The daily rhythm of temperature was continuously recorded using a telemetric device and salivary cortisol was recorded every 3 hours from 6:00AM to 9:00PM over 24 hours. BVL patients displayed a similar rest activity cycle during the day to control participants but had higher nocturnal actigraphy, mainly during weekdays. Sleep efficiency was reduced in patients compared to control participants. Patients had a marked temperature rhythm but with a significant phase advance (73 min) and a higher variability of the acrophase (from 2:24 PM to 9:25 PM) with no correlation to rest-activity cycle, contrary to healthy participants. Salivary cortisol levels were higher in patients compared to healthy people at any time of day. CONCLUSION: We observed a marked circadian rhythmicity of temperature in patients with BVL, probably due to the influence of the light dark cycle. However, the lack of synchronization between the temperature and rest-activity cycle supports the hypothesis that the vestibular inputs are salient input to the circadian clock that enhance the stabilization and precision of both external and internal entrainment. Public Library of Science 2016-06-24 /pmc/articles/PMC4920359/ /pubmed/27341473 http://dx.doi.org/10.1371/journal.pone.0155067 Text en © 2016 Martin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Martin, Tristan
Moussay, Sébastien
Bulla, Ingo
Bulla, Jan
Toupet, Michel
Etard, Olivier
Denise, Pierre
Davenne, Damien
Coquerel, Antoine
Quarck, Gaëlle
Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss
title Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss
title_full Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss
title_fullStr Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss
title_full_unstemmed Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss
title_short Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss
title_sort exploration of circadian rhythms in patients with bilateral vestibular loss
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920359/
https://www.ncbi.nlm.nih.gov/pubmed/27341473
http://dx.doi.org/10.1371/journal.pone.0155067
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