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C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease

Parkinson´s disease (PD) is characterized by the presence of proteinaceous inclusions called Lewy bodies that are mainly composed of α-synuclein (αSyn). Elevated levels of oxidative or nitrative stresses have been implicated in αSyn related toxicity. Phosphorylation of αSyn on serine 129 (S129) modu...

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Detalles Bibliográficos
Autores principales:	Kleinknecht, Alexandra, Popova, Blagovesta, Lázaro, Diana F., Pinho, Raquel, Valerius, Oliver, Outeiro, Tiago F., Braus, Gerhard H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920419/ https://www.ncbi.nlm.nih.gov/pubmed/27341336 http://dx.doi.org/10.1371/journal.pgen.1006098

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