Amplification of WHSC1L1 regulates expression and estrogen‐independent activation of ERα in SUM‐44 breast cancer cells and is associated with ERα over‐expression in breast cancer

The 8p11‐p12 amplicon occurs in approximately 15% of breast cancers in aggressive luminal B‐type tumors. Previously, we identified WHSC1L1 as a driving oncogene from this region. Here, we demonstrate that over‐expression of WHSC1L1 is linked to over‐expression of ERα in SUM‐44 breast cancer cells an...

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Detalles Bibliográficos
Autores principales: Irish, Jonathan C., Mills, Jamie N., Turner-Ivey, Brittany, Wilson, Robert C., Guest, Stephen T., Rutkovsky, Alexandria, Dombkowski, Alan, Kappler, Christiana S., Hardiman, Gary, Ethier, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920706/
https://www.ncbi.nlm.nih.gov/pubmed/27005559
http://dx.doi.org/10.1016/j.molonc.2016.02.003

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