Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

OBJECTIVE: Acute pancreatitis is caused by toxins that induce acinar cell calcium overload, zymogen activation, cytokine release and cell death, yet is without specific drug therapy. Mitochondrial dysfunction has been implicated but the mechanism not established. DESIGN: We investigated the mechanis...

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Detalles Bibliográficos
Autores principales: Mukherjee, Rajarshi, Mareninova, Olga A, Odinokova, Irina V, Huang, Wei, Murphy, John, Chvanov, Michael, Javed, Muhammad A, Wen, Li, Booth, David M, Cane, Matthew C, Awais, Muhammad, Gavillet, Bruno, Pruss, Rebecca M, Schaller, Sophie, Molkentin, Jeffery D, Tepikin, Alexei V, Petersen, Ole H, Pandol, Stephen J, Gukovsky, Ilya, Criddle, David N, Gukovskaya, Anna S, Sutton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920725/
https://www.ncbi.nlm.nih.gov/pubmed/26071131
http://dx.doi.org/10.1136/gutjnl-2014-308553

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