Cargando…
Mechanism-Oriented Therapy of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common and well-accepted diagnosis but often imprecisely applied to patients in usual clinical practice. Diagnosis is entirely based on symptom criteria that tend to include broad strata of abdominal complainers. Established criteria for diagnosis are strictly fol...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920845/ https://www.ncbi.nlm.nih.gov/pubmed/27138605 http://dx.doi.org/10.1007/s12325-016-0336-3 |
_version_ | 1782439443816251392 |
---|---|
author | Malagelada, Juan R. Malagelada, Carolina |
author_facet | Malagelada, Juan R. Malagelada, Carolina |
author_sort | Malagelada, Juan R. |
collection | PubMed |
description | Irritable bowel syndrome (IBS) is a common and well-accepted diagnosis but often imprecisely applied to patients in usual clinical practice. Diagnosis is entirely based on symptom criteria that tend to include broad strata of abdominal complainers. Established criteria for diagnosis are strictly followed in controlled clinical trials for new therapeutic agents, but physicians are more lax in the clinic. Predictably, in light of the above ambiguities, many pathogenetic mechanisms and pathophysiological disturbances appear to be involved in IBS, but so far no mechanism-based subgroupings to guide specific therapy have been soundly established. Thus, diverse therapeutic approaches coexist and are discretionally prescribed by attending clinicians on the basis of major manifestations (i.e., diarrhea-predominance or constipation-predominance), more or less apparent psychological disturbances, and patient preferences (pharmacological versus dietary or microbiological approaches). In this review, we have attempted to update scientific knowledge about the more relevant disease mechanisms involved and relate this more fundamental basis to the various treatment options available today. |
format | Online Article Text |
id | pubmed-4920845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-49208452016-07-12 Mechanism-Oriented Therapy of Irritable Bowel Syndrome Malagelada, Juan R. Malagelada, Carolina Adv Ther Review Irritable bowel syndrome (IBS) is a common and well-accepted diagnosis but often imprecisely applied to patients in usual clinical practice. Diagnosis is entirely based on symptom criteria that tend to include broad strata of abdominal complainers. Established criteria for diagnosis are strictly followed in controlled clinical trials for new therapeutic agents, but physicians are more lax in the clinic. Predictably, in light of the above ambiguities, many pathogenetic mechanisms and pathophysiological disturbances appear to be involved in IBS, but so far no mechanism-based subgroupings to guide specific therapy have been soundly established. Thus, diverse therapeutic approaches coexist and are discretionally prescribed by attending clinicians on the basis of major manifestations (i.e., diarrhea-predominance or constipation-predominance), more or less apparent psychological disturbances, and patient preferences (pharmacological versus dietary or microbiological approaches). In this review, we have attempted to update scientific knowledge about the more relevant disease mechanisms involved and relate this more fundamental basis to the various treatment options available today. Springer Healthcare 2016-04-30 2016 /pmc/articles/PMC4920845/ /pubmed/27138605 http://dx.doi.org/10.1007/s12325-016-0336-3 Text en © The Author(s) 2016 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Malagelada, Juan R. Malagelada, Carolina Mechanism-Oriented Therapy of Irritable Bowel Syndrome |
title | Mechanism-Oriented Therapy of Irritable Bowel Syndrome |
title_full | Mechanism-Oriented Therapy of Irritable Bowel Syndrome |
title_fullStr | Mechanism-Oriented Therapy of Irritable Bowel Syndrome |
title_full_unstemmed | Mechanism-Oriented Therapy of Irritable Bowel Syndrome |
title_short | Mechanism-Oriented Therapy of Irritable Bowel Syndrome |
title_sort | mechanism-oriented therapy of irritable bowel syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920845/ https://www.ncbi.nlm.nih.gov/pubmed/27138605 http://dx.doi.org/10.1007/s12325-016-0336-3 |
work_keys_str_mv | AT malageladajuanr mechanismorientedtherapyofirritablebowelsyndrome AT malageladacarolina mechanismorientedtherapyofirritablebowelsyndrome |