Potential Roles of Adropin in Central Nervous System: Review of Current Literature

Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordin...

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Autores principales: Shahjouei, Shima, Ansari, Saeed, Pourmotabbed, Tayebeh, Zand, Ramin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921473/
https://www.ncbi.nlm.nih.gov/pubmed/27446928
http://dx.doi.org/10.3389/fmolb.2016.00025
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author Shahjouei, Shima
Ansari, Saeed
Pourmotabbed, Tayebeh
Zand, Ramin
author_facet Shahjouei, Shima
Ansari, Saeed
Pourmotabbed, Tayebeh
Zand, Ramin
author_sort Shahjouei, Shima
collection PubMed
description Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.
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spelling pubmed-49214732016-07-21 Potential Roles of Adropin in Central Nervous System: Review of Current Literature Shahjouei, Shima Ansari, Saeed Pourmotabbed, Tayebeh Zand, Ramin Front Mol Biosci Molecular Biosciences Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed. Frontiers Media S.A. 2016-06-27 /pmc/articles/PMC4921473/ /pubmed/27446928 http://dx.doi.org/10.3389/fmolb.2016.00025 Text en Copyright © 2016 Shahjouei, Ansari, Pourmotabbed and Zand. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Shahjouei, Shima
Ansari, Saeed
Pourmotabbed, Tayebeh
Zand, Ramin
Potential Roles of Adropin in Central Nervous System: Review of Current Literature
title Potential Roles of Adropin in Central Nervous System: Review of Current Literature
title_full Potential Roles of Adropin in Central Nervous System: Review of Current Literature
title_fullStr Potential Roles of Adropin in Central Nervous System: Review of Current Literature
title_full_unstemmed Potential Roles of Adropin in Central Nervous System: Review of Current Literature
title_short Potential Roles of Adropin in Central Nervous System: Review of Current Literature
title_sort potential roles of adropin in central nervous system: review of current literature
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921473/
https://www.ncbi.nlm.nih.gov/pubmed/27446928
http://dx.doi.org/10.3389/fmolb.2016.00025
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