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Regeneration of Zebrafish CNS: Adult Neurogenesis

Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibia...

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Detalles Bibliográficos
Autores principales: Ghosh, Sukla, Hui, Subhra Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921647/
https://www.ncbi.nlm.nih.gov/pubmed/27382491
http://dx.doi.org/10.1155/2016/5815439
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author Ghosh, Sukla
Hui, Subhra Prakash
author_facet Ghosh, Sukla
Hui, Subhra Prakash
author_sort Ghosh, Sukla
collection PubMed
description Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibians are capable of regenerating a variety of complex organs through epimorphosis. Zebrafish is an excellent animal model, which can repair several organs like damaged retina, severed spinal cord, injured brain and heart, and amputated fins. The focus of the present paper is on spinal cord regeneration in adult zebrafish. We intend to discuss our current understanding of the cellular and molecular mechanism(s) that allows formation of proliferating progenitors and controls neurogenesis, which involve changes in epigenetic and transcription programs. Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system. Injury induced proliferation involves radial glia which proliferate, transcribe embryonic genes, and can give rise to new neurons. Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming.
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spelling pubmed-49216472016-07-05 Regeneration of Zebrafish CNS: Adult Neurogenesis Ghosh, Sukla Hui, Subhra Prakash Neural Plast Review Article Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibians are capable of regenerating a variety of complex organs through epimorphosis. Zebrafish is an excellent animal model, which can repair several organs like damaged retina, severed spinal cord, injured brain and heart, and amputated fins. The focus of the present paper is on spinal cord regeneration in adult zebrafish. We intend to discuss our current understanding of the cellular and molecular mechanism(s) that allows formation of proliferating progenitors and controls neurogenesis, which involve changes in epigenetic and transcription programs. Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system. Injury induced proliferation involves radial glia which proliferate, transcribe embryonic genes, and can give rise to new neurons. Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming. Hindawi Publishing Corporation 2016 2016-06-13 /pmc/articles/PMC4921647/ /pubmed/27382491 http://dx.doi.org/10.1155/2016/5815439 Text en Copyright © 2016 S. Ghosh and S. P. Hui. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ghosh, Sukla
Hui, Subhra Prakash
Regeneration of Zebrafish CNS: Adult Neurogenesis
title Regeneration of Zebrafish CNS: Adult Neurogenesis
title_full Regeneration of Zebrafish CNS: Adult Neurogenesis
title_fullStr Regeneration of Zebrafish CNS: Adult Neurogenesis
title_full_unstemmed Regeneration of Zebrafish CNS: Adult Neurogenesis
title_short Regeneration of Zebrafish CNS: Adult Neurogenesis
title_sort regeneration of zebrafish cns: adult neurogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921647/
https://www.ncbi.nlm.nih.gov/pubmed/27382491
http://dx.doi.org/10.1155/2016/5815439
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