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Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy

To establish a versatile means for screening and management of nonalcoholic steatohepatitis (NASH), shear wave velocity was measured in 20 normal controls and 138 consecutive nonalcoholic fatty liver disease (NAFLD) cases. Referencing biochemical properties in 679 healthy volunteers, a formula to di...

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Autores principales: Hirose, Kanae, Kanefuji, Tsutomu, Suda, Takeshi, Sugitani, Souichi, Nagasaki, Keisuke, Kubota, Tomoyuki, Igarashi, Masato, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921726/
https://www.ncbi.nlm.nih.gov/pubmed/27382367
http://dx.doi.org/10.1155/2016/6343656
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author Hirose, Kanae
Kanefuji, Tsutomu
Suda, Takeshi
Sugitani, Souichi
Nagasaki, Keisuke
Kubota, Tomoyuki
Igarashi, Masato
Terai, Shuji
author_facet Hirose, Kanae
Kanefuji, Tsutomu
Suda, Takeshi
Sugitani, Souichi
Nagasaki, Keisuke
Kubota, Tomoyuki
Igarashi, Masato
Terai, Shuji
author_sort Hirose, Kanae
collection PubMed
description To establish a versatile means for screening and management of nonalcoholic steatohepatitis (NASH), shear wave velocity was measured in 20 normal controls and 138 consecutive nonalcoholic fatty liver disease (NAFLD) cases. Referencing biochemical properties in 679 healthy volunteers, a formula to distinguish NASH suspects was established and validated in another cohort of 138 histologically proven NAFLD cases. NASH and simple steatosis (SS) suspects were selected based on a plot of shear wave velocity against age. A formula consisting of five factors (γ-glutamyl transpeptidase, alkaline phosphatase, platelet counts, body mass index, and presence/absence of type 2 diabetes mellitus) distinguished NASH suspects from SS suspects with area under the receiver operating characteristic curve values of 86% and 84% in the development and validation cohorts. Among 25 NAFLD cases in which shear wave velocity was repeatedly measured, 8 and 9 cases revealed an increase or decrease, respectively, of shear wave velocity in the entire liver, and the corresponding change in shear wave velocity was primarily observed in the right lobe or the left lateral segment, respectively. These results suggest that the new formula and sequential shear wave velocity measurements at each segment enable high throughput screening of NASH suspects and noninvasive assessment of pathophysiological alleviation/aggravation in cases of NASH.
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spelling pubmed-49217262016-07-05 Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy Hirose, Kanae Kanefuji, Tsutomu Suda, Takeshi Sugitani, Souichi Nagasaki, Keisuke Kubota, Tomoyuki Igarashi, Masato Terai, Shuji Gastroenterol Res Pract Research Article To establish a versatile means for screening and management of nonalcoholic steatohepatitis (NASH), shear wave velocity was measured in 20 normal controls and 138 consecutive nonalcoholic fatty liver disease (NAFLD) cases. Referencing biochemical properties in 679 healthy volunteers, a formula to distinguish NASH suspects was established and validated in another cohort of 138 histologically proven NAFLD cases. NASH and simple steatosis (SS) suspects were selected based on a plot of shear wave velocity against age. A formula consisting of five factors (γ-glutamyl transpeptidase, alkaline phosphatase, platelet counts, body mass index, and presence/absence of type 2 diabetes mellitus) distinguished NASH suspects from SS suspects with area under the receiver operating characteristic curve values of 86% and 84% in the development and validation cohorts. Among 25 NAFLD cases in which shear wave velocity was repeatedly measured, 8 and 9 cases revealed an increase or decrease, respectively, of shear wave velocity in the entire liver, and the corresponding change in shear wave velocity was primarily observed in the right lobe or the left lateral segment, respectively. These results suggest that the new formula and sequential shear wave velocity measurements at each segment enable high throughput screening of NASH suspects and noninvasive assessment of pathophysiological alleviation/aggravation in cases of NASH. Hindawi Publishing Corporation 2016 2016-06-13 /pmc/articles/PMC4921726/ /pubmed/27382367 http://dx.doi.org/10.1155/2016/6343656 Text en Copyright © 2016 Kanae Hirose et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hirose, Kanae
Kanefuji, Tsutomu
Suda, Takeshi
Sugitani, Souichi
Nagasaki, Keisuke
Kubota, Tomoyuki
Igarashi, Masato
Terai, Shuji
Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy
title Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy
title_full Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy
title_fullStr Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy
title_full_unstemmed Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy
title_short Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy
title_sort formulation for effective screening and management of nonalcoholic steatohepatitis: noninvasive nafld management strategy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921726/
https://www.ncbi.nlm.nih.gov/pubmed/27382367
http://dx.doi.org/10.1155/2016/6343656
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