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Encoding of mechanical nociception differs in the adult and infant brain

Newborn human infants display robust pain behaviour and specific cortical activity following noxious skin stimulation, but it is not known whether brain processing of nociceptive information differs in infants and adults. Imaging studies have emphasised the overlap between infant and adult brain con...

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Autores principales: Fabrizi, Lorenzo, Verriotis, Madeleine, Williams, Gemma, Lee, Amy, Meek, Judith, Olhede, Sofia, Fitzgerald, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921818/
https://www.ncbi.nlm.nih.gov/pubmed/27345331
http://dx.doi.org/10.1038/srep28642
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author Fabrizi, Lorenzo
Verriotis, Madeleine
Williams, Gemma
Lee, Amy
Meek, Judith
Olhede, Sofia
Fitzgerald, Maria
author_facet Fabrizi, Lorenzo
Verriotis, Madeleine
Williams, Gemma
Lee, Amy
Meek, Judith
Olhede, Sofia
Fitzgerald, Maria
author_sort Fabrizi, Lorenzo
collection PubMed
description Newborn human infants display robust pain behaviour and specific cortical activity following noxious skin stimulation, but it is not known whether brain processing of nociceptive information differs in infants and adults. Imaging studies have emphasised the overlap between infant and adult brain connectome architecture, but electrophysiological analysis of infant brain nociceptive networks can provide further understanding of the functional postnatal development of pain perception. Here we hypothesise that the human infant brain encodes noxious information with different neuronal patterns compared to adults. To test this we compared EEG responses to the same time-locked noxious skin lance in infants aged 0–19 days (n = 18, clinically required) and adults aged 23–48 years (n = 21). Time-frequency analysis revealed that while some features of adult nociceptive network activity are present in infants at longer latencies, including beta-gamma oscillations, infants display a distinct, long latency, noxious evoked 18-fold energy increase in the fast delta band (2–4 Hz) that is absent in adults. The differences in activity between infants and adults have a widespread topographic distribution across the brain. These data support our hypothesis and indicate important postnatal changes in the encoding of mechanical pain in the human brain.
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spelling pubmed-49218182016-06-28 Encoding of mechanical nociception differs in the adult and infant brain Fabrizi, Lorenzo Verriotis, Madeleine Williams, Gemma Lee, Amy Meek, Judith Olhede, Sofia Fitzgerald, Maria Sci Rep Article Newborn human infants display robust pain behaviour and specific cortical activity following noxious skin stimulation, but it is not known whether brain processing of nociceptive information differs in infants and adults. Imaging studies have emphasised the overlap between infant and adult brain connectome architecture, but electrophysiological analysis of infant brain nociceptive networks can provide further understanding of the functional postnatal development of pain perception. Here we hypothesise that the human infant brain encodes noxious information with different neuronal patterns compared to adults. To test this we compared EEG responses to the same time-locked noxious skin lance in infants aged 0–19 days (n = 18, clinically required) and adults aged 23–48 years (n = 21). Time-frequency analysis revealed that while some features of adult nociceptive network activity are present in infants at longer latencies, including beta-gamma oscillations, infants display a distinct, long latency, noxious evoked 18-fold energy increase in the fast delta band (2–4 Hz) that is absent in adults. The differences in activity between infants and adults have a widespread topographic distribution across the brain. These data support our hypothesis and indicate important postnatal changes in the encoding of mechanical pain in the human brain. Nature Publishing Group 2016-06-27 /pmc/articles/PMC4921818/ /pubmed/27345331 http://dx.doi.org/10.1038/srep28642 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Fabrizi, Lorenzo
Verriotis, Madeleine
Williams, Gemma
Lee, Amy
Meek, Judith
Olhede, Sofia
Fitzgerald, Maria
Encoding of mechanical nociception differs in the adult and infant brain
title Encoding of mechanical nociception differs in the adult and infant brain
title_full Encoding of mechanical nociception differs in the adult and infant brain
title_fullStr Encoding of mechanical nociception differs in the adult and infant brain
title_full_unstemmed Encoding of mechanical nociception differs in the adult and infant brain
title_short Encoding of mechanical nociception differs in the adult and infant brain
title_sort encoding of mechanical nociception differs in the adult and infant brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921818/
https://www.ncbi.nlm.nih.gov/pubmed/27345331
http://dx.doi.org/10.1038/srep28642
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