The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor

In acute myeloid leukemia (AML), the Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes. Recently, a new and recurrent juxtamembrane deletion mutation (p.Q569Vfs*2) resulting in a truncated receptor was identified. The mutated receptor is expressed on the cell surface and...

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Detalles Bibliográficos
Autores principales: Sandhöfer, Nadine, Bauer, Julia, Reiter, Katrin, Dufour, Annika, Rothenberg, Maja, Konstandin, Nikola P., Zellmeier, Evelyn, Tizazu, Belay, Greif, Philipp A., Metzeler, Klaus H., Hiddemann, Wolfgang, Polzer, Harald, Spiekermann, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921855/
https://www.ncbi.nlm.nih.gov/pubmed/27346558
http://dx.doi.org/10.1038/srep28032

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