Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation

Although extracellular signal-related kinase 1/2 (ERK 1/2) activity is generally associated with cell survival, prolonged ERK activation induced by oxidative stress also mediates neuronal cell death. Here we report that oxidative stress-induced cyclin-dependent kinase 5 (CDK5) activation stimulates...

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Detalles Bibliográficos
Autores principales: Song, Haengjin, Kim, Wanil, Choi, Jung-Hyun, Kim, Sung-Hoon, Lee, Dohyun, Park, Choon-Ho, Kim, Sangjune, Kim, Do-Yeon, Kim, Kyong-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922050/
https://www.ncbi.nlm.nih.gov/pubmed/27346674
http://dx.doi.org/10.1038/srep28634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922050/
https://www.ncbi.nlm.nih.gov/pubmed/27346674
http://dx.doi.org/10.1038/srep28634

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