Cargando…

Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation

Although extracellular signal-related kinase 1/2 (ERK 1/2) activity is generally associated with cell survival, prolonged ERK activation induced by oxidative stress also mediates neuronal cell death. Here we report that oxidative stress-induced cyclin-dependent kinase 5 (CDK5) activation stimulates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Haengjin, Kim, Wanil, Choi, Jung-Hyun, Kim, Sung-Hoon, Lee, Dohyun, Park, Choon-Ho, Kim, Sangjune, Kim, Do-Yeon, Kim, Kyong-Tai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922050/ https://www.ncbi.nlm.nih.gov/pubmed/27346674 http://dx.doi.org/10.1038/srep28634

Ejemplares similares

VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity
por: Song, Haengjin, et al.
Publicado: (2016)

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer
por: Lee, Namgyu, et al.
Publicado: (2017)

VRK-1 extends life span by activation of AMPK via phosphorylation
por: Park, Sangsoon, et al.
Publicado: (2020)

HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence
por: Choi, Yoon Ha, et al.
Publicado: (2012)

HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation
por: Ryu, Hye Guk, et al.
Publicado: (2021)

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis
por: Park, Choon-Ho, et al.
Publicado: (2011)

VRK2A is an A-type lamin–dependent nuclear envelope kinase that phosphorylates BAF
por: Birendra KC,, et al.
Publicado: (2017)

ERK-mediated phosphorylation of BIS regulates nuclear translocation of HSF1 under oxidative stress
por: Kim, Hye Yun, et al.
Publicado: (2016)

Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
por: Sohn, Hoyoung, et al.
Publicado: (2014)

Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity
por: Lee, Eunju, et al.
Publicado: (2016)

Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease
por: Kim, Sangjune, et al.
Publicado: (2014)

Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1
por: Aplin, Andrew E., et al.
Publicado: (2001)

Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1
por: Jeong, Min-Woo, et al.
Publicado: (2013)

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53
por: Valbuena, Alberto, et al.
Publicado: (2008)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
por: Sanz-García, Marta, et al.
Publicado: (2008)

ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth
por: Park, Jongmin, et al.
Publicado: (2022)

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
por: Vázquez-Cedeira, Marta, et al.
Publicado: (2011)

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
por: Shields, Julie A., et al.
Publicado: (2022)

Gentisic Acid Stimulates Keratinocyte Proliferation through ERK1/2 Phosphorylation
por: Kim, Minho, et al.
Publicado: (2020)

Apoptotic Phosphorylation of Histone H3 on Ser-10 by Protein Kinase Cδ
por: Park, Choon-Ho, et al.
Publicado: (2012)

MicroRNA-185 oscillation controls circadian amplitude of mouse Cryptochrome 1 via translational regulation
por: Lee, Kyung-Ha, et al.
Publicado: (2013)

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
por: Yang, Weiwei, et al.
Publicado: (2012)

Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
por: Shindo, Yuki, et al.
Publicado: (2016)

Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson’s disease
por: Yan, Jianguo, et al.
Publicado: (2022)

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
por: Valbuena, Alberto, et al.
Publicado: (2011)

Mouse period 2 mRNA circadian oscillation is modulated by PTB–mediated rhythmic mRNA degradation
por: Woo, Kyung-Chul, et al.
Publicado: (2009)

Dissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis
por: Cartwright, Tyrell N., et al.
Publicado: (2022)

YB-1 Phosphorylation at Serine 209 Inhibits Its Nuclear Translocation
por: Sogorina, Ekaterina M., et al.
Publicado: (2021)

Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage
por: Du, Ning, et al.
Publicado: (2023)

Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-κB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells
por: Lee, Jae-Won, et al.
Publicado: (2013)

B-cell translocation gene 1 is downregulated by promoter methylation in ovarian carcinoma
por: Kim, Ji-Ye, et al.
Publicado: (2017)

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
por: So, Jonathan, et al.
Publicado: (2022)

PTBP1 Positively Regulates the Translation of Circadian Clock Gene, Period1
por: Kim, Wanil, et al.
Publicado: (2020)

RNA-Binding Proteins and the Complex Pathophysiology of ALS
por: Kim, Wanil, et al.
Publicado: (2021)

Regulation of Gene Expression by Telomere Position Effect
por: Lee, Kyung-Ha, et al.
Publicado: (2021)

CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP(+)-induced Parkinson’s disease model
por: Jiao, Feng-Juan, et al.
Publicado: (2017)

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
por: Sang, Youzhou, et al.
Publicado: (2019)

Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer
por: Maik-Rachline, Galia, et al.
Publicado: (2019)

NANOG Is Multiply Phosphorylated and Directly Modified by ERK2 and CDK1 In Vitro
por: Brumbaugh, Justin, et al.
Publicado: (2014)

Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2
por: Kim, Hwang-Phill, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_lbk09eo4lc09sd7ru7hrhl6uc1