Blood lipids influence DNA methylation in circulating cells

BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To...

Descripción completa

Detalles Bibliográficos
Autores principales: Dekkers, Koen F., van Iterson, Maarten, Slieker, Roderick C., Moed, Matthijs H., Bonder, Marc Jan, van Galen, Michiel, Mei, Hailiang, Zhernakova, Daria V., van den Berg, Leonard H., Deelen, Joris, van Dongen, Jenny, van Heemst, Diana, Hofman, Albert, Hottenga, Jouke J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Stehouwer, Coen D. A., Tigchelaar, Ettje F., Uitterlinden, André G., Willemsen, Gonneke, Zhernakova, Alexandra, Franke, Lude, ’t Hoen, Peter A. C., Jansen, Rick, van Meurs, Joyce, Boomsma, Dorret I., van Duijn, Cornelia M., van Greevenbroek, Marleen M. J., Veldink, Jan H., Wijmenga, Cisca, van Zwet, Erik W., Slagboom, P. Eline, Jukema, J. Wouter, Heijmans, Bastiaan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922056/
https://www.ncbi.nlm.nih.gov/pubmed/27350042
http://dx.doi.org/10.1186/s13059-016-1000-6

Ejemplares similares

Ejemplares similares