A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemia

BACKGROUND: BCR-ABL1 fusion proteins contain constitutively active tyrosine kinases that are potential candidates for targeted therapy with tyrosine kinase inhibitors such as imatinib in chronic myeloid leukemia (CML). However, uncharacterized BCR-ABL1 fusion genes can be missed by quantitative RT-P...

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Detalles Bibliográficos
Autores principales: Lyu, Xiaodong, Yang, Jingke, Wang, Xianwei, Hu, Jieying, Liu, Bing, Zhao, Yu, Guo, Zhen, Liu, Bingshan, Fan, Ruihua, Song, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922057/
https://www.ncbi.nlm.nih.gov/pubmed/27350795
http://dx.doi.org/10.1186/s13039-016-0257-5

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