A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs

BACKGROUND: Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only o...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Guo, Weiwei, Ren, Lili, Yang, Mingyao, Zhao, Yaofeng, Guo, Zongyi, Yi, Haijin, Li, Mingzhou, Hu, Yiqing, Long, Xi, Sun, Boyuan, Li, Jinxiu, Zhai, Suoqiang, Zhang, Tinghuan, Tian, Shilin, Meng, Qingyong, Yu, Ning, Zhu, Dan, Tang, Guoqing, Tang, Qianzi, Ren, Liming, Liu, Ke, Zhang, Shihua, Che, Tiandong, Yu, Zhengquan, Wu, Nan, Jing, Lan, Zhang, Ran, Cong, Tao, Chen, Siqing, Zhao, Yiqiang, Zhang, Yue, Bai, Xiaoqing, Guo, Ying, Zhao, Lidong, Zhang, Fengming, Zhao, Hui, Zhang, Liang, Hou, Zhaohui, Zhao, Jiugang, Li, Jianan, Zhang, Lijuan, Sun, Wei, Zou, Xiangang, Wang, Tao, Ge, Liangpeng, Liu, Zuohua, Hu, Xiaoxiang, Wang, Jingyong, Yang, Shiming, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922063/
https://www.ncbi.nlm.nih.gov/pubmed/27349893
http://dx.doi.org/10.1186/s12915-016-0273-2

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