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Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults

BACKGROUND: Hyponatremia and vitamin D deficiency are frequent disorders, and both have been associated with gait disturbances, falls and fractures. The aim of this study was to evaluate the existence of an association between serum sodium and vitamin D serum levels. METHODS: We performed a retrospe...

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Autores principales: Cervellin, Gianfranco, Salvagno, Gianluca, Bonfanti, Laura, Bonelli, Patrizia, Guidi, Gian Cesare, Lippi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922356/
https://www.ncbi.nlm.nih.gov/pubmed/28356854
http://dx.doi.org/10.1515/jomb-2015-0003
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author Cervellin, Gianfranco
Salvagno, Gianluca
Bonfanti, Laura
Bonelli, Patrizia
Guidi, Gian Cesare
Lippi, Giuseppe
author_facet Cervellin, Gianfranco
Salvagno, Gianluca
Bonfanti, Laura
Bonelli, Patrizia
Guidi, Gian Cesare
Lippi, Giuseppe
author_sort Cervellin, Gianfranco
collection PubMed
description BACKGROUND: Hyponatremia and vitamin D deficiency are frequent disorders, and both have been associated with gait disturbances, falls and fractures. The aim of this study was to evaluate the existence of an association between serum sodium and vitamin D serum levels. METHODS: We performed a retrospective investigation to establish whether hyponatremia and vitamin D deficiency may be associated in a general population of unselected outpatients. An electronic search was performed in the laboratory information systems of the Hospital of Verona and the Hospital of Parma (Italy), to retrieve combined results for total vitamin D and sodium obtained in all outpatients referred for health check-up in the year 2013. RESULTS: Combined results of vitamin D and sodium could be retrieved for 5097 outpatients (3859 females and 1238 males; mean age 64±17 years). Vitamin D deficient subjects displayed significantly lower levels of serum sodium (140 versus 141 mmol/L; p<0.001), along with a significantly higher rate of hyponatremia (6.3% versus 5.1%; p=0.037). Accordingly, hyponatremic subjects had significantly lower levels of serum vitamin D (55 versus 60 nmol/L; p=0.015), along with a significantly higher rate of vitamin D deficiency (41.8% versus 36.1%; p=0.030). A highly significant correlation was found between sodium and total vitamin D after adjustment for age and gender (p<0.001). CONCLUSIONS: The results of this study demonstrate for the first time the existence of a significant correlation between the serum levels of sodium and total vitamin D in a general population of unselected outpatients.
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spelling pubmed-49223562017-03-29 Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults Cervellin, Gianfranco Salvagno, Gianluca Bonfanti, Laura Bonelli, Patrizia Guidi, Gian Cesare Lippi, Giuseppe J Med Biochem Original Paper BACKGROUND: Hyponatremia and vitamin D deficiency are frequent disorders, and both have been associated with gait disturbances, falls and fractures. The aim of this study was to evaluate the existence of an association between serum sodium and vitamin D serum levels. METHODS: We performed a retrospective investigation to establish whether hyponatremia and vitamin D deficiency may be associated in a general population of unselected outpatients. An electronic search was performed in the laboratory information systems of the Hospital of Verona and the Hospital of Parma (Italy), to retrieve combined results for total vitamin D and sodium obtained in all outpatients referred for health check-up in the year 2013. RESULTS: Combined results of vitamin D and sodium could be retrieved for 5097 outpatients (3859 females and 1238 males; mean age 64±17 years). Vitamin D deficient subjects displayed significantly lower levels of serum sodium (140 versus 141 mmol/L; p<0.001), along with a significantly higher rate of hyponatremia (6.3% versus 5.1%; p=0.037). Accordingly, hyponatremic subjects had significantly lower levels of serum vitamin D (55 versus 60 nmol/L; p=0.015), along with a significantly higher rate of vitamin D deficiency (41.8% versus 36.1%; p=0.030). A highly significant correlation was found between sodium and total vitamin D after adjustment for age and gender (p<0.001). CONCLUSIONS: The results of this study demonstrate for the first time the existence of a significant correlation between the serum levels of sodium and total vitamin D in a general population of unselected outpatients. Society of Medical Biochemists of Serbia 2015-10 2015-09-19 /pmc/articles/PMC4922356/ /pubmed/28356854 http://dx.doi.org/10.1515/jomb-2015-0003 Text en © 2015 Gianfranco Cervellin et al., published by De Gruyter Open http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Original Paper
Cervellin, Gianfranco
Salvagno, Gianluca
Bonfanti, Laura
Bonelli, Patrizia
Guidi, Gian Cesare
Lippi, Giuseppe
Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults
title Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults
title_full Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults
title_fullStr Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults
title_full_unstemmed Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults
title_short Association of Hyponatremia and Hypovitaminosis D in Ambulatory Adults
title_sort association of hyponatremia and hypovitaminosis d in ambulatory adults
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922356/
https://www.ncbi.nlm.nih.gov/pubmed/28356854
http://dx.doi.org/10.1515/jomb-2015-0003
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