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Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients

BACKGROUND: Clonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while approximately 15 million were distributed in China. Hepatitis B virus (HBV) infection is a major public health issue. Two types of pathogens hav...

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Autores principales: Li, Wenfang, Dong, Huimin, Huang, Yan, Chen, Tingjin, Kong, Xiangzhan, Sun, Hengchang, Yu, Xinbing, Xu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922651/
https://www.ncbi.nlm.nih.gov/pubmed/27348302
http://dx.doi.org/10.1371/journal.pntd.0004806
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author Li, Wenfang
Dong, Huimin
Huang, Yan
Chen, Tingjin
Kong, Xiangzhan
Sun, Hengchang
Yu, Xinbing
Xu, Jin
author_facet Li, Wenfang
Dong, Huimin
Huang, Yan
Chen, Tingjin
Kong, Xiangzhan
Sun, Hengchang
Yu, Xinbing
Xu, Jin
author_sort Li, Wenfang
collection PubMed
description BACKGROUND: Clonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while approximately 15 million were distributed in China. Hepatitis B virus (HBV) infection is a major public health issue. Two types of pathogens have the potential to cause human liver disease and eventually hepatocellular carcinoma. Concurrent infection with HBV and C. sinensis is often observed in some areas where C. sinensis is endemic. However, whether C. sinensis could impact HBV infection or vice versa remains unknown. PRINCIPAL FINDINGS: Co-infection with C. sinensis and HBV develops predominantly in males. Co-infected C. sinensis and HBV patients presented weaker liver function and higher HBV DNA titers. Combination treatment with antiviral and anti-C. sinensis drugs in co-infected patients could contribute to a reduction in viral load and help with liver function recovery. Excretory-secretory products (ESPs) may, in some ways, increase HBV viral replication in vitro. A mixture of ESP and HBV positive sera could induce peripheral blood mononuclear cells (PBMCs) to produce higher level of Th2 cytokines including IL-4, IL-6 and IL-10 compared to HBV alone, it seems that due to presence of ESP, the cytokine production shift towards Th2. C. sinensis/HBV co-infected patients showed higher serum IL-6 and IL-10 levels and lower serum IFN-γ levels. CONCLUSIONS/SIGNIFICANCE: Patients with concomitant C. sinensis and HBV infection presented weaker liver function and higher HBV DNA copies. In co-infected patients, the efficacy of anti-viral treatment was better in patients who were prescribed with entecavir and praziquantel than entecavir alone. One possible reason for the weaker response to antiviral therapies in co-infected patients was the shift in cytokine production from Th1 to Th2 that may inhibit viral clearance. C. sinensis/HBV co-infection could exacerbate the imbalance of Th1/Th2 cytokine.
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spelling pubmed-49226512016-07-18 Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients Li, Wenfang Dong, Huimin Huang, Yan Chen, Tingjin Kong, Xiangzhan Sun, Hengchang Yu, Xinbing Xu, Jin PLoS Negl Trop Dis Research Article BACKGROUND: Clonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while approximately 15 million were distributed in China. Hepatitis B virus (HBV) infection is a major public health issue. Two types of pathogens have the potential to cause human liver disease and eventually hepatocellular carcinoma. Concurrent infection with HBV and C. sinensis is often observed in some areas where C. sinensis is endemic. However, whether C. sinensis could impact HBV infection or vice versa remains unknown. PRINCIPAL FINDINGS: Co-infection with C. sinensis and HBV develops predominantly in males. Co-infected C. sinensis and HBV patients presented weaker liver function and higher HBV DNA titers. Combination treatment with antiviral and anti-C. sinensis drugs in co-infected patients could contribute to a reduction in viral load and help with liver function recovery. Excretory-secretory products (ESPs) may, in some ways, increase HBV viral replication in vitro. A mixture of ESP and HBV positive sera could induce peripheral blood mononuclear cells (PBMCs) to produce higher level of Th2 cytokines including IL-4, IL-6 and IL-10 compared to HBV alone, it seems that due to presence of ESP, the cytokine production shift towards Th2. C. sinensis/HBV co-infected patients showed higher serum IL-6 and IL-10 levels and lower serum IFN-γ levels. CONCLUSIONS/SIGNIFICANCE: Patients with concomitant C. sinensis and HBV infection presented weaker liver function and higher HBV DNA copies. In co-infected patients, the efficacy of anti-viral treatment was better in patients who were prescribed with entecavir and praziquantel than entecavir alone. One possible reason for the weaker response to antiviral therapies in co-infected patients was the shift in cytokine production from Th1 to Th2 that may inhibit viral clearance. C. sinensis/HBV co-infection could exacerbate the imbalance of Th1/Th2 cytokine. Public Library of Science 2016-06-27 /pmc/articles/PMC4922651/ /pubmed/27348302 http://dx.doi.org/10.1371/journal.pntd.0004806 Text en © 2016 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Wenfang
Dong, Huimin
Huang, Yan
Chen, Tingjin
Kong, Xiangzhan
Sun, Hengchang
Yu, Xinbing
Xu, Jin
Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients
title Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients
title_full Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients
title_fullStr Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients
title_full_unstemmed Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients
title_short Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients
title_sort clonorchis sinensis co-infection could affect the disease state and treatment response of hbv patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922651/
https://www.ncbi.nlm.nih.gov/pubmed/27348302
http://dx.doi.org/10.1371/journal.pntd.0004806
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