A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation

10-Hydroxycamptothecin (10-HCPT) is a promising anticancer drug with a wide spectrum of antitumor activities. Due to its poor solubility, the carboxylate form that shows high water solubility but minimal anticancer activity and pharmacokinetic defects is used in the marketed 10-HCPT injections, resu...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Xiaofeng, Liu, Yingying, Zhao, Yanna, Han, Meihua, Guo, Yifei, Kuang, Haixue, Wang, Xiangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922823/
https://www.ncbi.nlm.nih.gov/pubmed/27382284
http://dx.doi.org/10.2147/IJN.S102726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922823/
https://www.ncbi.nlm.nih.gov/pubmed/27382284
http://dx.doi.org/10.2147/IJN.S102726

Ejemplares similares