Frequencies of ALK rearrangements in lung adenocarcinoma subtypes: a study of 2299 Chinese cases

PURPOSE: This study aimed to determine the relationship between ALK status and lung adenocarcinoma subtypes, according to the IALSC/ATS/ERS classification in Chinese patients. METHODS: A reclassification of 2299 surgically resected lung adenocarcinomas was performed, and ALK status was detected by i...

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Detalles Bibliográficos
Autores principales: Yu, Yongfeng, Ding, Zhengping, Zhu, Lei, Teng, Haohua, Lu, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923004/
https://www.ncbi.nlm.nih.gov/pubmed/27386342
http://dx.doi.org/10.1186/s40064-016-2607-5
Descripción
Sumario:PURPOSE: This study aimed to determine the relationship between ALK status and lung adenocarcinoma subtypes, according to the IALSC/ATS/ERS classification in Chinese patients. METHODS: A reclassification of 2299 surgically resected lung adenocarcinomas was performed, and ALK status was detected by immunohistochemistry (Ventana Medical Systems) in Shanghai Chest Hospital. RESULTS: ALK rearrangements were identified in 93 of 2299 tumors (4.0 %). The ALK rearrangements frequencies were: 14.8 % (16/108), 10.3 % (20/195), 7.6 % (13/170), 2.8 % (29/1035), 2.5 % (3/119), 2.0 % (11/539), 0.9 % (1/114), and 0 % (0/19) for variants of invasive adenocarcinoma, solid predominant, micropapillary predominant, acinar predominant, minimally invasive adenocarcinoma, papillary predominant, lepidic predominant, and adenocarcinoma in situ, respectively. CONCLUSIONS: We reported significant discrepancies of ALK status in lung adenocarcinoma subtypes in Chinese patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40064-016-2607-5) contains supplementary material, which is available to authorized users.

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