Cargando…

Hypothesis and Theory: Revisiting Views on the Co-evolution of the Melanocortin Receptors and the Accessory Proteins, MRAP1 and MRAP2

The evolution of the melanocortin receptors (MCRs) is closely associated with the evolution of the melanocortin-2 receptor accessory proteins (MRAPs). Recent annotation of the elephant shark genome project revealed the sequence of a putative MRAP1 ortholog. The presence of this sequence in the genom...

Descripción completa

Detalles Bibliográficos
Autor principal:	Dores, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923161/ https://www.ncbi.nlm.nih.gov/pubmed/27445982 http://dx.doi.org/10.3389/fendo.2016.00079

Ejemplares similares

Hypothesis and Theory: Evaluating the Co-Evolution of the Melanocortin-2 Receptor and the Accessory Protein MRAP1
por: Dores, Robert M., et al.
Publicado: (2021)

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis
por: Tai, Xiaolu, et al.
Publicado: (2022)

Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey
por: Zhu, Ming, et al.
Publicado: (2019)

MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus)
por: Wen, Zheng-Yong, et al.
Publicado: (2021)

Structure/Function Studies on the Activation Motif of Two Non-Mammalian Mrap1 Orthologs, and Observations on the Phylogeny of Mrap1, Including a Novel Characterization of an Mrap1 from the Chondrostean Fish, Polyodon spathula
por: Dores, Robert M., et al.
Publicado: (2022)

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
por: Wang, Meng, et al.
Publicado: (2021)

Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure
por: Bruschetta, Giuseppe, et al.
Publicado: (2018)

Regulation of Melanocortin-5 Receptor Pharmacology by Two Isoforms of MRAP2 in Ricefield Eel (Monopterus albus)
por: Liu, Ting, et al.
Publicado: (2021)

Human Melanocortin-2 Receptor: Identifying a Role for Residues in the TM4, EC2, and TM5 Domains in Activation and Trafficking as a Result of Co-Expression with the Accessory Protein, Mrap1 in Chinese Hamster Ovary Cells
por: Davis, Perry V., et al.
Publicado: (2022)

Determination of the Interaction and Pharmacological Modulation of MCHR1 Signaling by the C-Terminus of MRAP2 Protein
por: Wang, Meng, et al.
Publicado: (2022)

MRAP2 regulates ghrelin receptor signaling and hunger sensing
por: Srisai, Dollada, et al.
Publicado: (2017)

Identification of MRAP protein family as broad‐spectrum GPCR modulators
por: Wang, Meng, et al.
Publicado: (2022)

Arginine 125 Is an Essential Residue for the Function of MRAP2
por: Fullone, Maria Rosaria, et al.
Publicado: (2022)

The melanocortin receptors and their accessory proteins
por: Ramachandrappa, Shwetha, et al.
Publicado: (2013)

hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation
por: Kay, Emma I., et al.
Publicado: (2015)

In Vitro Splicing Assay Proves the Pathogenicity of Intronic Variants in MRAP
por: Smith, Chris, et al.
Publicado: (2021)

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation
por: Novoselova, Tatiana V., et al.
Publicado: (2018)

The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells
por: Yin, Terry C., et al.
Publicado: (2020)

Melanocortin receptor accessory proteins in adrenal disease and obesity
por: Jackson, David S., et al.
Publicado: (2015)

Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol
por: Novoselova, T V, et al.
Publicado: (2016)

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension
por: Baron, Morgane, et al.
Publicado: (2019)

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling
por: Wang, Xiaozhu, et al.
Publicado: (2022)

Dual Topology of the Melanocortin-2 Receptor Accessory Protein Is Stable
por: Maben, Zachary J., et al.
Publicado: (2016)

MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation
por: Rouault, Alix A.J., et al.
Publicado: (2022)

Neonatal presentation of familial glucocorticoid deficiency with a MRAP mutation: A case report()
por: Chen, Chun, et al.
Publicado: (2016)

Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)
por: Tao, Min, et al.
Publicado: (2020)

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R
por: Bernard, Adelaide, et al.
Publicado: (2023)

Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling
por: Xu, Jing, et al.
Publicado: (2022)

Observations on the Evolution of the Melanocortin Receptor Gene Family: Distinctive Features of the Melanocortin-2 Receptor
por: Dores, Robert M.
Publicado: (2013)

OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R
por: Bernard, Adelaide A, et al.
Publicado: (2020)

Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency
por: Dias, R P, et al.
Publicado: (2010)

OR0302 Regulation Of Human Melanocortin-5 Receptor By Isoforms Of Melanocortin-2 Receptor Accessory Proteins
por: Jiang, Shanshan, et al.
Publicado: (2023)

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor
por: Soletto, Lucia, et al.
Publicado: (2018)

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2
por: Ji, Ren-Lei, et al.
Publicado: (2022)

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2
por: Ji, Ren-Lei, et al.
Publicado: (2022)

Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors
por: Wang, Meng, et al.
Publicado: (2022)

Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2
por: Ji, Ren-Lei, et al.
Publicado: (2021)

Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor
por: Davis, Perry E., et al.
Publicado: (2019)

PSUN97 Regulation of melanocortin-3 and -4 receptors by isoforms of melanocortin-2 receptor accessory protein 1 and 2
por: Ji, Ren-Lei, et al.
Publicado: (2022)

Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors
por: Takahashi, Akiyoshi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0uajihip4g1md97tcgfdatfb0g