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Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes

Diabetes is often associated with chronic kidney disease (CKD) and is the primary cause of kidney failure in half of patients who receive dialysis therapy. Given the increasing prevalence of diabetes and its high morbidity and mortality, diabetic nephropathy is a serious drawback in individual patie...

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Detalles Bibliográficos
Autores principales: Kim, Sang Soo, Kim, Jong Ho, Kim, In Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923408/
https://www.ncbi.nlm.nih.gov/pubmed/27246284
http://dx.doi.org/10.3803/EnM.2016.31.2.245
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author Kim, Sang Soo
Kim, Jong Ho
Kim, In Joo
author_facet Kim, Sang Soo
Kim, Jong Ho
Kim, In Joo
author_sort Kim, Sang Soo
collection PubMed
description Diabetes is often associated with chronic kidney disease (CKD) and is the primary cause of kidney failure in half of patients who receive dialysis therapy. Given the increasing prevalence of diabetes and its high morbidity and mortality, diabetic nephropathy is a serious drawback in individual patients and a tremendous socioeconomic burden on society. Despite growing concern for the management of diabetic nephropathy, the prevalence of CKD with diabetes is the same today as it was 20 years ago. The current strategy to manage diabetic nephropathy, including the control of hyperglycemia, dyslipidemia, and blood pressure and the wide-spread use of renin-angiotensin-aldosterone system inhibitors, is well established to be beneficial in the early stages of diabetic nephropathy. However, the effects are uncertain in patients with relatively progressed CKD. Therefore, early diagnosis or risk verification is extremely important in order to reduce the individual and socioeconomic burdens associated with diabetic nephropathy by providing appropriate management to prevent the development and progression of this condition. This review focuses on recent research and guidelines regarding risk assessment, advances in medical treatment, and challenges of and future treatments for diabetic nephropathy.
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spelling pubmed-49234082016-07-07 Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes Kim, Sang Soo Kim, Jong Ho Kim, In Joo Endocrinol Metab (Seoul) Review Article Diabetes is often associated with chronic kidney disease (CKD) and is the primary cause of kidney failure in half of patients who receive dialysis therapy. Given the increasing prevalence of diabetes and its high morbidity and mortality, diabetic nephropathy is a serious drawback in individual patients and a tremendous socioeconomic burden on society. Despite growing concern for the management of diabetic nephropathy, the prevalence of CKD with diabetes is the same today as it was 20 years ago. The current strategy to manage diabetic nephropathy, including the control of hyperglycemia, dyslipidemia, and blood pressure and the wide-spread use of renin-angiotensin-aldosterone system inhibitors, is well established to be beneficial in the early stages of diabetic nephropathy. However, the effects are uncertain in patients with relatively progressed CKD. Therefore, early diagnosis or risk verification is extremely important in order to reduce the individual and socioeconomic burdens associated with diabetic nephropathy by providing appropriate management to prevent the development and progression of this condition. This review focuses on recent research and guidelines regarding risk assessment, advances in medical treatment, and challenges of and future treatments for diabetic nephropathy. Korean Endocrine Society 2016-06 2016-05-27 /pmc/articles/PMC4923408/ /pubmed/27246284 http://dx.doi.org/10.3803/EnM.2016.31.2.245 Text en Copyright © 2016 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Sang Soo
Kim, Jong Ho
Kim, In Joo
Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
title Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
title_full Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
title_fullStr Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
title_full_unstemmed Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
title_short Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
title_sort current challenges in diabetic nephropathy: early diagnosis and ways to improve outcomes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923408/
https://www.ncbi.nlm.nih.gov/pubmed/27246284
http://dx.doi.org/10.3803/EnM.2016.31.2.245
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