Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine rec...

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Detalles Bibliográficos
Autores principales: Liao, Xiaofeng, Pirapakaran, Tharshikha, Luo, Xin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923605/
https://www.ncbi.nlm.nih.gov/pubmed/27403037
http://dx.doi.org/10.1155/2016/6012715
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author Liao, Xiaofeng
Pirapakaran, Tharshikha
Luo, Xin M.
author_facet Liao, Xiaofeng
Pirapakaran, Tharshikha
Luo, Xin M.
author_sort Liao, Xiaofeng
collection PubMed
description Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine receptor system is necessary for leukocyte recruitment. In this review, we summarize recent studies on the roles of chemokines and chemokine receptors in the development of LN and discuss the potential and hurdles of developing novel, chemokine-based drugs to treat LN.
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spelling pubmed-49236052016-07-11 Chemokines and Chemokine Receptors in the Development of Lupus Nephritis Liao, Xiaofeng Pirapakaran, Tharshikha Luo, Xin M. Mediators Inflamm Review Article Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine receptor system is necessary for leukocyte recruitment. In this review, we summarize recent studies on the roles of chemokines and chemokine receptors in the development of LN and discuss the potential and hurdles of developing novel, chemokine-based drugs to treat LN. Hindawi Publishing Corporation 2016 2016-06-14 /pmc/articles/PMC4923605/ /pubmed/27403037 http://dx.doi.org/10.1155/2016/6012715 Text en Copyright © 2016 Xiaofeng Liao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liao, Xiaofeng
Pirapakaran, Tharshikha
Luo, Xin M.
Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
title Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
title_full Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
title_fullStr Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
title_full_unstemmed Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
title_short Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
title_sort chemokines and chemokine receptors in the development of lupus nephritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923605/
https://www.ncbi.nlm.nih.gov/pubmed/27403037
http://dx.doi.org/10.1155/2016/6012715
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