Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats

Background: P38 mitogen activated protein kinase (MAPK) α modulates microglia-mediated inflammatory responses and a number of neuronal physiological processes. Objective: To evaluate pre-clinically the pharmacological effects in the brain of p38 MAPKα inhibition with a brain-penetrant specific chemi...

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Detalles Bibliográficos
Autor principal: Alam, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923728/
https://www.ncbi.nlm.nih.gov/pubmed/26401942
http://dx.doi.org/10.3233/JAD-150277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923728/
https://www.ncbi.nlm.nih.gov/pubmed/26401942
http://dx.doi.org/10.3233/JAD-150277

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