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Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause

Background: Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman’s body after menopause and different genetic variants are still being sought. M...

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Autores principales: Rył, Aleksandra, Jasiewicz, Andrzej, Grzywacz, Anna, Adler, Grażyna, Skonieczna-Żydecka, Karolina, Rotter, Iwona, Sipak-Szmigiel, Olimpia, Rumianowski, Bogdan, Karakiewicz, Beata, Jurczak, Anna, Parczewski, Miłosz, Urbańska, Anna, Grabowska, Marta, Laszczyńska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924000/
https://www.ncbi.nlm.nih.gov/pubmed/27240396
http://dx.doi.org/10.3390/ijerph13060543
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author Rył, Aleksandra
Jasiewicz, Andrzej
Grzywacz, Anna
Adler, Grażyna
Skonieczna-Żydecka, Karolina
Rotter, Iwona
Sipak-Szmigiel, Olimpia
Rumianowski, Bogdan
Karakiewicz, Beata
Jurczak, Anna
Parczewski, Miłosz
Urbańska, Anna
Grabowska, Marta
Laszczyńska, Maria
author_facet Rył, Aleksandra
Jasiewicz, Andrzej
Grzywacz, Anna
Adler, Grażyna
Skonieczna-Żydecka, Karolina
Rotter, Iwona
Sipak-Szmigiel, Olimpia
Rumianowski, Bogdan
Karakiewicz, Beata
Jurczak, Anna
Parczewski, Miłosz
Urbańska, Anna
Grabowska, Marta
Laszczyńska, Maria
author_sort Rył, Aleksandra
collection PubMed
description Background: Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman’s body after menopause and different genetic variants are still being sought. Methods: The study was conducted in 252 women who had completed physiological menopause. The women were divided into groups according to the time elapsed since menopause. The total concentrations of estradiol and follicle-stimulating hormone were determined by means of electrochemiluminescence. The apolipoprotein E (APOE) and lepitn (LEP) genotypes were determined by real-time PCR and polymerase chain reaction–restriction fragment length polymorphism, respectively. Results: We observed that people with the APOE3/E3 genotype entered menopause insignificantly later compared to other genotypes. Additionally, in the group of patients with the APOE3/E3 genotypes, differences in the E2 concentration were significantly related to the time since their last menstruation. There is no association found in the literature between these polymorphisms of the LEP gene and hormones. Conclusions: To date, attempts to formulate a model describing the association between E2 and FSH concentration with the polymorphisms of various genes of menopause in women have not been successful. This relationship is difficult to study because of the number of nongenetic factors. Environmental factors can explain variation in postmenopausal changes in hormone levels.
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spelling pubmed-49240002016-07-05 Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause Rył, Aleksandra Jasiewicz, Andrzej Grzywacz, Anna Adler, Grażyna Skonieczna-Żydecka, Karolina Rotter, Iwona Sipak-Szmigiel, Olimpia Rumianowski, Bogdan Karakiewicz, Beata Jurczak, Anna Parczewski, Miłosz Urbańska, Anna Grabowska, Marta Laszczyńska, Maria Int J Environ Res Public Health Article Background: Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman’s body after menopause and different genetic variants are still being sought. Methods: The study was conducted in 252 women who had completed physiological menopause. The women were divided into groups according to the time elapsed since menopause. The total concentrations of estradiol and follicle-stimulating hormone were determined by means of electrochemiluminescence. The apolipoprotein E (APOE) and lepitn (LEP) genotypes were determined by real-time PCR and polymerase chain reaction–restriction fragment length polymorphism, respectively. Results: We observed that people with the APOE3/E3 genotype entered menopause insignificantly later compared to other genotypes. Additionally, in the group of patients with the APOE3/E3 genotypes, differences in the E2 concentration were significantly related to the time since their last menstruation. There is no association found in the literature between these polymorphisms of the LEP gene and hormones. Conclusions: To date, attempts to formulate a model describing the association between E2 and FSH concentration with the polymorphisms of various genes of menopause in women have not been successful. This relationship is difficult to study because of the number of nongenetic factors. Environmental factors can explain variation in postmenopausal changes in hormone levels. MDPI 2016-05-28 2016-06 /pmc/articles/PMC4924000/ /pubmed/27240396 http://dx.doi.org/10.3390/ijerph13060543 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rył, Aleksandra
Jasiewicz, Andrzej
Grzywacz, Anna
Adler, Grażyna
Skonieczna-Żydecka, Karolina
Rotter, Iwona
Sipak-Szmigiel, Olimpia
Rumianowski, Bogdan
Karakiewicz, Beata
Jurczak, Anna
Parczewski, Miłosz
Urbańska, Anna
Grabowska, Marta
Laszczyńska, Maria
Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
title Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
title_full Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
title_fullStr Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
title_full_unstemmed Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
title_short Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
title_sort analysis of the relationship between estradiol and follicle-stimulating hormone concentrations and polymorphisms of apolipoprotein e and leptingenes in women post-menopause
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924000/
https://www.ncbi.nlm.nih.gov/pubmed/27240396
http://dx.doi.org/10.3390/ijerph13060543
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