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Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients

Many long-term maintenance hemodialysis patients have symptoms of protein-energy wasting caused by malnutrition. Each session of hemodialysis removes about 10 to 12 g of amino acids and 200 to 480 kcal of energy. Patients receiving hemodialysis for chronic kidney disease may be undernourished for en...

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Autores principales: Liu, Yan, Xiao, Xiao, Qin, Dan-Ping, Tan, Rong-Shao, Zhong, Xiao-Shi, Zhou, Dao-Yuan, Liu, Yun, Xiong, Xuan, Zheng, Yuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924157/
https://www.ncbi.nlm.nih.gov/pubmed/27271658
http://dx.doi.org/10.3390/nu8060220
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author Liu, Yan
Xiao, Xiao
Qin, Dan-Ping
Tan, Rong-Shao
Zhong, Xiao-Shi
Zhou, Dao-Yuan
Liu, Yun
Xiong, Xuan
Zheng, Yuan-Yuan
author_facet Liu, Yan
Xiao, Xiao
Qin, Dan-Ping
Tan, Rong-Shao
Zhong, Xiao-Shi
Zhou, Dao-Yuan
Liu, Yun
Xiong, Xuan
Zheng, Yuan-Yuan
author_sort Liu, Yan
collection PubMed
description Many long-term maintenance hemodialysis patients have symptoms of protein-energy wasting caused by malnutrition. Each session of hemodialysis removes about 10 to 12 g of amino acids and 200 to 480 kcal of energy. Patients receiving hemodialysis for chronic kidney disease may be undernourished for energy, protein consumption, or both. Non-diabetic hemodialysis patients were randomized to three treatment groups: oral supplementation, oral supplementation plus high-concentration glucose solution (250 mL containing 50% glucose) and these two interventions plus 8.5% amino acids solution. The post-treatment energy status of the glucose group was significantly higher than its baseline level, whereas the control group’s status was significantly lower. The glucose group had significantly higher concentrations of asparagine, glutamine, glycine, alanine, and lysine after treatment. All treatment groups had significantly increased hemoglobin levels but significantly decreased transferrin levels after treatment compared to baseline. After treatment, the amino acid group had significantly higher albumin level compared to the glucose group (p = 0.001) and significantly higher prealbumin level compared to the control group (p = 0.017). In conclusion, long-term intervention with high-concentration glucose solution at each hemodialysis session is a simple and cheap method that replenished energy stores lost during hemodialysis of non-diabetic patients.
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spelling pubmed-49241572016-07-05 Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients Liu, Yan Xiao, Xiao Qin, Dan-Ping Tan, Rong-Shao Zhong, Xiao-Shi Zhou, Dao-Yuan Liu, Yun Xiong, Xuan Zheng, Yuan-Yuan Nutrients Article Many long-term maintenance hemodialysis patients have symptoms of protein-energy wasting caused by malnutrition. Each session of hemodialysis removes about 10 to 12 g of amino acids and 200 to 480 kcal of energy. Patients receiving hemodialysis for chronic kidney disease may be undernourished for energy, protein consumption, or both. Non-diabetic hemodialysis patients were randomized to three treatment groups: oral supplementation, oral supplementation plus high-concentration glucose solution (250 mL containing 50% glucose) and these two interventions plus 8.5% amino acids solution. The post-treatment energy status of the glucose group was significantly higher than its baseline level, whereas the control group’s status was significantly lower. The glucose group had significantly higher concentrations of asparagine, glutamine, glycine, alanine, and lysine after treatment. All treatment groups had significantly increased hemoglobin levels but significantly decreased transferrin levels after treatment compared to baseline. After treatment, the amino acid group had significantly higher albumin level compared to the glucose group (p = 0.001) and significantly higher prealbumin level compared to the control group (p = 0.017). In conclusion, long-term intervention with high-concentration glucose solution at each hemodialysis session is a simple and cheap method that replenished energy stores lost during hemodialysis of non-diabetic patients. MDPI 2016-06-02 /pmc/articles/PMC4924157/ /pubmed/27271658 http://dx.doi.org/10.3390/nu8060220 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Yan
Xiao, Xiao
Qin, Dan-Ping
Tan, Rong-Shao
Zhong, Xiao-Shi
Zhou, Dao-Yuan
Liu, Yun
Xiong, Xuan
Zheng, Yuan-Yuan
Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
title Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
title_full Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
title_fullStr Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
title_full_unstemmed Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
title_short Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
title_sort comparison of intradialytic parenteral nutrition with glucose or amino acid mixtures in maintenance hemodialysis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924157/
https://www.ncbi.nlm.nih.gov/pubmed/27271658
http://dx.doi.org/10.3390/nu8060220
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