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Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either pro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924180/ https://www.ncbi.nlm.nih.gov/pubmed/27271661 http://dx.doi.org/10.3390/nu8060339 |
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author | Kanda, Atsushi Nakayama, Kyosuke Sanbongi, Chiaki Nagata, Masashi Ikegami, Shuji Itoh, Hiroyuki |
author_facet | Kanda, Atsushi Nakayama, Kyosuke Sanbongi, Chiaki Nagata, Masashi Ikegami, Shuji Itoh, Hiroyuki |
author_sort | Kanda, Atsushi |
collection | PubMed |
description | Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either protein alone. We therefore compared the effect of ingesting milk protein (MP) to either WP or CA alone on muscle protein synthesis after exercise in rats. We also compared the effects of these milk-derived proteins to a control, soy protein (SP). Male Sprague-Dawley rats swam for two hours. Immediately after exercise, one of the following four solutions was administered: WP, CA, MP, or SP. Individual rats were euthanized at designated postprandial time points and triceps muscle samples collected for measurement of the protein fractional synthesis rate (FSR). FSR tended to increase in all groups post-ingestion, although the initial peaks of FSR occurred at different times (WP, peak time = 60 min, FSR = 7.76%/day; MP, peak time = 90 min, FSR = 8.34%/day; CA, peak time = 120 min, FSR = 7.85%/day). Milk-derived proteins caused significantly greater increases (p < 0.05) in FSR compared with SP at different times (WP, 60 min; MP, 90 and 120 min; CA, 120 min). Although statistical analysis could not be performed, the calculated the area under the curve (AUC) values for FSR following this trend were: MP, 534.61; CA, 498.22; WP, 473.46; and SP, 406.18. We conclude that ingestion of MP, CA or WP causes the initial peak time in muscle protein synthesis to occur at different times (WP, fast; MP, intermediate; CA, slow) and the dairy proteins have a superior effect on muscle protein synthesis after exercise compared with SP. |
format | Online Article Text |
id | pubmed-4924180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49241802016-07-05 Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise Kanda, Atsushi Nakayama, Kyosuke Sanbongi, Chiaki Nagata, Masashi Ikegami, Shuji Itoh, Hiroyuki Nutrients Article Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either protein alone. We therefore compared the effect of ingesting milk protein (MP) to either WP or CA alone on muscle protein synthesis after exercise in rats. We also compared the effects of these milk-derived proteins to a control, soy protein (SP). Male Sprague-Dawley rats swam for two hours. Immediately after exercise, one of the following four solutions was administered: WP, CA, MP, or SP. Individual rats were euthanized at designated postprandial time points and triceps muscle samples collected for measurement of the protein fractional synthesis rate (FSR). FSR tended to increase in all groups post-ingestion, although the initial peaks of FSR occurred at different times (WP, peak time = 60 min, FSR = 7.76%/day; MP, peak time = 90 min, FSR = 8.34%/day; CA, peak time = 120 min, FSR = 7.85%/day). Milk-derived proteins caused significantly greater increases (p < 0.05) in FSR compared with SP at different times (WP, 60 min; MP, 90 and 120 min; CA, 120 min). Although statistical analysis could not be performed, the calculated the area under the curve (AUC) values for FSR following this trend were: MP, 534.61; CA, 498.22; WP, 473.46; and SP, 406.18. We conclude that ingestion of MP, CA or WP causes the initial peak time in muscle protein synthesis to occur at different times (WP, fast; MP, intermediate; CA, slow) and the dairy proteins have a superior effect on muscle protein synthesis after exercise compared with SP. MDPI 2016-06-03 /pmc/articles/PMC4924180/ /pubmed/27271661 http://dx.doi.org/10.3390/nu8060339 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanda, Atsushi Nakayama, Kyosuke Sanbongi, Chiaki Nagata, Masashi Ikegami, Shuji Itoh, Hiroyuki Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise |
title | Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise |
title_full | Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise |
title_fullStr | Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise |
title_full_unstemmed | Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise |
title_short | Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise |
title_sort | effects of whey, caseinate, or milk protein ingestion on muscle protein synthesis after exercise |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924180/ https://www.ncbi.nlm.nih.gov/pubmed/27271661 http://dx.doi.org/10.3390/nu8060339 |
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