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Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise

Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either pro...

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Autores principales: Kanda, Atsushi, Nakayama, Kyosuke, Sanbongi, Chiaki, Nagata, Masashi, Ikegami, Shuji, Itoh, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924180/
https://www.ncbi.nlm.nih.gov/pubmed/27271661
http://dx.doi.org/10.3390/nu8060339
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author Kanda, Atsushi
Nakayama, Kyosuke
Sanbongi, Chiaki
Nagata, Masashi
Ikegami, Shuji
Itoh, Hiroyuki
author_facet Kanda, Atsushi
Nakayama, Kyosuke
Sanbongi, Chiaki
Nagata, Masashi
Ikegami, Shuji
Itoh, Hiroyuki
author_sort Kanda, Atsushi
collection PubMed
description Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either protein alone. We therefore compared the effect of ingesting milk protein (MP) to either WP or CA alone on muscle protein synthesis after exercise in rats. We also compared the effects of these milk-derived proteins to a control, soy protein (SP). Male Sprague-Dawley rats swam for two hours. Immediately after exercise, one of the following four solutions was administered: WP, CA, MP, or SP. Individual rats were euthanized at designated postprandial time points and triceps muscle samples collected for measurement of the protein fractional synthesis rate (FSR). FSR tended to increase in all groups post-ingestion, although the initial peaks of FSR occurred at different times (WP, peak time = 60 min, FSR = 7.76%/day; MP, peak time = 90 min, FSR = 8.34%/day; CA, peak time = 120 min, FSR = 7.85%/day). Milk-derived proteins caused significantly greater increases (p < 0.05) in FSR compared with SP at different times (WP, 60 min; MP, 90 and 120 min; CA, 120 min). Although statistical analysis could not be performed, the calculated the area under the curve (AUC) values for FSR following this trend were: MP, 534.61; CA, 498.22; WP, 473.46; and SP, 406.18. We conclude that ingestion of MP, CA or WP causes the initial peak time in muscle protein synthesis to occur at different times (WP, fast; MP, intermediate; CA, slow) and the dairy proteins have a superior effect on muscle protein synthesis after exercise compared with SP.
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spelling pubmed-49241802016-07-05 Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise Kanda, Atsushi Nakayama, Kyosuke Sanbongi, Chiaki Nagata, Masashi Ikegami, Shuji Itoh, Hiroyuki Nutrients Article Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either protein alone. We therefore compared the effect of ingesting milk protein (MP) to either WP or CA alone on muscle protein synthesis after exercise in rats. We also compared the effects of these milk-derived proteins to a control, soy protein (SP). Male Sprague-Dawley rats swam for two hours. Immediately after exercise, one of the following four solutions was administered: WP, CA, MP, or SP. Individual rats were euthanized at designated postprandial time points and triceps muscle samples collected for measurement of the protein fractional synthesis rate (FSR). FSR tended to increase in all groups post-ingestion, although the initial peaks of FSR occurred at different times (WP, peak time = 60 min, FSR = 7.76%/day; MP, peak time = 90 min, FSR = 8.34%/day; CA, peak time = 120 min, FSR = 7.85%/day). Milk-derived proteins caused significantly greater increases (p < 0.05) in FSR compared with SP at different times (WP, 60 min; MP, 90 and 120 min; CA, 120 min). Although statistical analysis could not be performed, the calculated the area under the curve (AUC) values for FSR following this trend were: MP, 534.61; CA, 498.22; WP, 473.46; and SP, 406.18. We conclude that ingestion of MP, CA or WP causes the initial peak time in muscle protein synthesis to occur at different times (WP, fast; MP, intermediate; CA, slow) and the dairy proteins have a superior effect on muscle protein synthesis after exercise compared with SP. MDPI 2016-06-03 /pmc/articles/PMC4924180/ /pubmed/27271661 http://dx.doi.org/10.3390/nu8060339 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanda, Atsushi
Nakayama, Kyosuke
Sanbongi, Chiaki
Nagata, Masashi
Ikegami, Shuji
Itoh, Hiroyuki
Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
title Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
title_full Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
title_fullStr Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
title_full_unstemmed Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
title_short Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise
title_sort effects of whey, caseinate, or milk protein ingestion on muscle protein synthesis after exercise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924180/
https://www.ncbi.nlm.nih.gov/pubmed/27271661
http://dx.doi.org/10.3390/nu8060339
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