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Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

BACKGROUND: Pancreatic cancer is one of the most lethal malignancies. The innovative treatments are required and now the cancer stem cells (CSCs) are expected to be an effective target for novel therapies. Therefore we investigated the significance of hedgehog (Hh) signaling in the maintenance of CS...

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Detalles Bibliográficos
Autores principales:	Miyazaki, Yumi, Matsubara, Shyuichirou, Ding, Qiang, Tsukasa, Koichiro, Yoshimitsu, Makoto, Kosai, Ken-ichiro, Takao, Sonshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924257/ https://www.ncbi.nlm.nih.gov/pubmed/27349387 http://dx.doi.org/10.1186/s12943-016-0534-2

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