MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?

We have recently identified in a transgenic mouse model of Alzheimer’s disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer’s pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-...

Descripción completa

Detalles Bibliográficos
Autores principales: Baranger, Kévin, Khrestchatisky, Michel, Rivera, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924292/
https://www.ncbi.nlm.nih.gov/pubmed/27349644
http://dx.doi.org/10.1186/s12974-016-0633-4
_version_ 1782439844549492736
author Baranger, Kévin
Khrestchatisky, Michel
Rivera, Santiago
author_facet Baranger, Kévin
Khrestchatisky, Michel
Rivera, Santiago
author_sort Baranger, Kévin
collection PubMed
description We have recently identified in a transgenic mouse model of Alzheimer’s disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer’s pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking.
format Online
Article
Text
id pubmed-4924292
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-49242922016-06-29 MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease? Baranger, Kévin Khrestchatisky, Michel Rivera, Santiago J Neuroinflammation Hypothesis We have recently identified in a transgenic mouse model of Alzheimer’s disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer’s pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking. BioMed Central 2016-06-28 /pmc/articles/PMC4924292/ /pubmed/27349644 http://dx.doi.org/10.1186/s12974-016-0633-4 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Hypothesis
Baranger, Kévin
Khrestchatisky, Michel
Rivera, Santiago
MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
title MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
title_full MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
title_fullStr MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
title_full_unstemmed MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
title_short MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
title_sort mt5-mmp, just a new app processing proteinase in alzheimer’s disease?
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924292/
https://www.ncbi.nlm.nih.gov/pubmed/27349644
http://dx.doi.org/10.1186/s12974-016-0633-4
work_keys_str_mv AT barangerkevin mt5mmpjustanewappprocessingproteinaseinalzheimersdisease
AT khrestchatiskymichel mt5mmpjustanewappprocessingproteinaseinalzheimersdisease
AT riverasantiago mt5mmpjustanewappprocessingproteinaseinalzheimersdisease

Ejemplares similares