Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody

BACKGROUND: Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is present only in skeletal and cardiac muscle and several pathogenic mutations occur w...

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Detalles Bibliográficos
Autores principales: Holt, Ian, Duong, Nguyen Thuy, Zhang, Qiuping, Lam, Le Thanh, Sewry, Caroline A., Mamchaoui, Kamel, Shanahan, Catherine M., Morris, Glenn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924313/
https://www.ncbi.nlm.nih.gov/pubmed/27350129
http://dx.doi.org/10.1186/s12860-016-0105-9

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