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The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis

BACKGROUND: Numerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted. METHOD...

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Autores principales: Ma, Ying-Yu, Wu, Wei-Quan, Liu, Zheng-Chuang, Yu, Xiao-Fen, Guo, Kun, He, Qi-Wen, Jiang, Shi-Bin, Shao, Qin-Shu, Tao, Hou-Quan, Huang, Dong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924327/
https://www.ncbi.nlm.nih.gov/pubmed/27349965
http://dx.doi.org/10.1186/s12957-016-0927-0
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author Ma, Ying-Yu
Wu, Wei-Quan
Liu, Zheng-Chuang
Yu, Xiao-Fen
Guo, Kun
He, Qi-Wen
Jiang, Shi-Bin
Shao, Qin-Shu
Tao, Hou-Quan
Huang, Dong-Sheng
author_facet Ma, Ying-Yu
Wu, Wei-Quan
Liu, Zheng-Chuang
Yu, Xiao-Fen
Guo, Kun
He, Qi-Wen
Jiang, Shi-Bin
Shao, Qin-Shu
Tao, Hou-Quan
Huang, Dong-Sheng
author_sort Ma, Ying-Yu
collection PubMed
description BACKGROUND: Numerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted. METHODS: A comprehensive search using the keywords “CDH1,” “E-Cadherin,” “polymorphism,” “SNP,” and “variant” combined with “breast,” “cancer,” “tumor,” or “carcinomas” was conducted. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were appropriately calculated using a fixed effect or random effect model. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 checklist was used for this meta-analysis. RESULTS: Four publications including five studies were identified. It was found that the CDH1 -160C/A polymorphism was significantly associated with breast cancer risk in the dominant model (CA + AA vs. CC: OR = 1.207, 95 % CI = 1.031–1.412, P = 0.019). CONCLUSIONS: Our meta-analysis demonstrated that the -160C/A polymorphism in the CDH1 gene might contribute to breast cancer susceptibility. Further investigations using a much larger sample including different ethnicities are still needed to verify this association. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-016-0927-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-49243272016-06-29 The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis Ma, Ying-Yu Wu, Wei-Quan Liu, Zheng-Chuang Yu, Xiao-Fen Guo, Kun He, Qi-Wen Jiang, Shi-Bin Shao, Qin-Shu Tao, Hou-Quan Huang, Dong-Sheng World J Surg Oncol Research BACKGROUND: Numerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted. METHODS: A comprehensive search using the keywords “CDH1,” “E-Cadherin,” “polymorphism,” “SNP,” and “variant” combined with “breast,” “cancer,” “tumor,” or “carcinomas” was conducted. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were appropriately calculated using a fixed effect or random effect model. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 checklist was used for this meta-analysis. RESULTS: Four publications including five studies were identified. It was found that the CDH1 -160C/A polymorphism was significantly associated with breast cancer risk in the dominant model (CA + AA vs. CC: OR = 1.207, 95 % CI = 1.031–1.412, P = 0.019). CONCLUSIONS: Our meta-analysis demonstrated that the -160C/A polymorphism in the CDH1 gene might contribute to breast cancer susceptibility. Further investigations using a much larger sample including different ethnicities are still needed to verify this association. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-016-0927-0) contains supplementary material, which is available to authorized users. BioMed Central 2016-06-27 /pmc/articles/PMC4924327/ /pubmed/27349965 http://dx.doi.org/10.1186/s12957-016-0927-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ma, Ying-Yu
Wu, Wei-Quan
Liu, Zheng-Chuang
Yu, Xiao-Fen
Guo, Kun
He, Qi-Wen
Jiang, Shi-Bin
Shao, Qin-Shu
Tao, Hou-Quan
Huang, Dong-Sheng
The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis
title The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis
title_full The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis
title_fullStr The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis
title_full_unstemmed The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis
title_short The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis
title_sort cdh1 -160c/a polymorphism is associated with breast cancer: evidence from a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924327/
https://www.ncbi.nlm.nih.gov/pubmed/27349965
http://dx.doi.org/10.1186/s12957-016-0927-0
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