The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer

Xerostomia is an important complication following radiotherapy (RT) for head and neck cancer. Current treatment approaches are insufficient and can only temporarily relieve symptoms. New insights into the physiopathology of radiation‐induced xerostomia might help us in this regard. This review discu...

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Detalles Bibliográficos
Autores principales: Nevens, Daan, Nuyts, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924373/
https://www.ncbi.nlm.nih.gov/pubmed/26880659
http://dx.doi.org/10.1002/cam4.609
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author Nevens, Daan
Nuyts, Sandra
author_facet Nevens, Daan
Nuyts, Sandra
author_sort Nevens, Daan
collection PubMed
description Xerostomia is an important complication following radiotherapy (RT) for head and neck cancer. Current treatment approaches are insufficient and can only temporarily relieve symptoms. New insights into the physiopathology of radiation‐induced xerostomia might help us in this regard. This review discusses the current knowledge of salivary gland stem cells in radiation‐induced xerostomia and their value in the prevention and treatment of this complication. Salivary gland stem cell transplantation, bone marrow‐derived cell mobilization, molecular regulation of parotid stem cells, stem cell sparing RT, and adaptive RT are promising techniques that are discussed in this study.
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spelling pubmed-49243732016-06-29 The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer Nevens, Daan Nuyts, Sandra Cancer Med Clinical Cancer Research Xerostomia is an important complication following radiotherapy (RT) for head and neck cancer. Current treatment approaches are insufficient and can only temporarily relieve symptoms. New insights into the physiopathology of radiation‐induced xerostomia might help us in this regard. This review discusses the current knowledge of salivary gland stem cells in radiation‐induced xerostomia and their value in the prevention and treatment of this complication. Salivary gland stem cell transplantation, bone marrow‐derived cell mobilization, molecular regulation of parotid stem cells, stem cell sparing RT, and adaptive RT are promising techniques that are discussed in this study. John Wiley and Sons Inc. 2016-02-16 /pmc/articles/PMC4924373/ /pubmed/26880659 http://dx.doi.org/10.1002/cam4.609 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Nevens, Daan
Nuyts, Sandra
The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
title The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
title_full The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
title_fullStr The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
title_full_unstemmed The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
title_short The role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
title_sort role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924373/
https://www.ncbi.nlm.nih.gov/pubmed/26880659
http://dx.doi.org/10.1002/cam4.609
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